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Fever threshold https://covid.joinzoe.com/post/fever-and-temperature https://www.medrxiv.org/content/10.1101/2021.01.26.21250480v1 Uninfected volunteers (twins), n = 1,089 Hospitalised, n = 1,227 Community based positives, n = 3,972 Results Among unaffected volunteers Lower BMI (p=0.001), and older age (p less than 0.001) associated with lower basal temperature Basal temperature showed a heritability of 47% In COVID-19+ participants Increasing age associated with lower temperatures (p less than 0.001) For each additional year of age, participants were 1% less likely to demonstrate a fever Ageing affects temperature in health and acute infection Older people with COVID-19 were also less likely to have a fever reaching 37.8°C Current health guidelines, 37.8°C or more should self-isolate Using a threshold of 37.4°C for over 65s is as sensitive and specific a sign of infection as 37.8°C in adults under 65 Global vaccine tracker https://www.bloomberg.com/graphics/covid-vaccine-tracker-global-distribution/ UK vaccine tracker https://coronavirus.data.gov.uk/details/vaccinations US vaccine tracker https://covid.cdc.gov/covid-data-tracker/#vaccinations Europe vaccine tracker https://data.spectator.co.uk/city/vaccines More vaccines for UK https://www.bbc.co.uk/news/health-55887264 Valneva, an extra 40 million doses, now 100million French, manufactured in Scotland Available late 2021, and into 2022 Flexibility Two doses, dead virus Fridge storage Nadhim Zahawi, any surplus vaccine could be distributed globally South Africa variant in Surrey https://www.bbc.co.uk/news/health-55889391 No known links to South Africa Identified, Public Health England's random checks Surge testing, door to door testing, London, Kent, Hertfordshire, Walsall US, Francis Collins, (National Institutes of Health) We’re very worried All it’s going to take is a couple more mutations on top of that, and you’re really going to have to start worrying Novavax trial, Previous infection did not provide full immunity to B.1.351 https://www.novavax.com/covid-19-coronavirus-vaccine-candidate-updates Efficacy against old strain = 95.6% Efficacy against UK variant = 85.6% Efficacy against SA variant = 60% United Kingdom, South Africa, Brazil all in US U.K. variant, B.1.1.7, 430 cases Brazil variant, P.1., Minnesota Jay Butler, Centers for Disease Control and Prevention If a more transmissible strain becomes dominant, herd immunity, 80 to 85 % Marc Lipsitch, Harvard, School of Public Health We will not be for decades dealing with a pandemic The concern is whether it will be a year or three years until we can make enough vaccines against enough strains to get this under control Israel https://www.theguardian.com/world/live/2021/feb/01/coronavirus-live-news-eu-wants-70-of-adults-vaccinated-by-end-of-summer-israel-extends-covid-lockdown Population, 9,053,000 Vaccinated, 54% (19.7% completed) Extends lockdown, started 27 December Airports and borders closed Persistent violations among ultra-Orthodox Thousands pack into funeral, 31st January Vaccinations complete end of March Japan https://www.washingtonpost.com/world/asia_pacific/japan-vaccine-delay-coronavirus/2021/01/30/a0b66322-5fd6-11eb-a177-7765f29a9524_story.html Vaccines are an essential part of national security (2016 report) Has not yet started vaccination (Australia and South Korea) Japanese vaccine, start-up AnGes in Osaka Phase III trials, late 2021 Own tests for imported vaccines Moderna vaccine trial began on Jan. 21, n = 200 people Finishes March 11 Approval, May 50 million doses ordered Oxford Astra Zeneca Approval, late February 90 million manufactured in country Olympics in July Vaccinations for over 65s, April Portugal Population, 10.2 million https://www.theguardian.com/world/live/2021/feb/01/coronavirus-live-news-eu-wants-70-of-adults-vaccinated-by-end-of-summer-israel-extends-covid-lockdown UK variant and relaxation of restrictions over Christmas The country had largely been spared by the first waves of the virus. Deaths, January, 5,576 = 12,482 Hospitals, close to being overwhelmed Santa Maria hospital, extra cold containers Mental health in the Pandemic Guernsey Dance festival, 19 – 22 January Mass spreader event, 186 cases Now locked down French warehouse, libertine party https://www.dailymail.co.uk/news/article-9204555/Police-break-French-warehouse-orgy-involving-100-people.html 100 arrested Collegien, Paris Everyone else under curfew Philadelphia https://www.washingtonpost.com/nation/2021/01/27/philly-fighting-covid-vaccine/ Assigned duties to unskilled young adults Start-up Philly Fighting COVID Largest coronavirus mass vaccination site Appointments not honoured For profit Sale of personal data Provisions that would allow Philly Fighting COVID to sell users’ personal data to a third party Unskilled people vaccinating each other

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