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New US vaccine and a missing mutant Analytics Table
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UK https://coronavirus.data.gov.uk/details/cases Cases, + 61,045 Down 21.2% Hospital admissions, + 8,460 Down 22.1% Deaths, + 2,270 Down 33.5% Vaccine, first dose, 20,089,551 Second dose, 796,132 https://assets.publishing.service.gov.uk/government/uploads/system/uploads/attachment_data/file/963532/COVID-19_vaccine_effectiveness_surveillance_report_February_2021_FINAL.pdf Pfizer in over 80s N = 11,860 cases in the UK Infections continue to decrease for four weeks after vaccination and then plateau Lower rate of admission amongst vaccinated, at least 14 days after a single dose Vaccinated individuals who do become symptomatic, protection against death. Pfizer in over 70s In context SIREN (Sarscov2 Immunity and REinfection EvaluatioN), protection against infection, after a single dose of Pfizer, 72% Israel that suggested 75% protection against all infections 85% against symptomatic infection after a single dose of Pfizer P1 variant https://www.bbc.co.uk/news/uk-56234302 Six found in the UK in February Unidentified person, infected with P1 variant, took a test 12th or 13th February Should be self-isolating for 10 days May or may not have flown into UK Hotel quarantine rule started 15th February United States Trends https://covid.cdc.gov/covid-data-tracker/#trends_dailytrendscases Hospitalizations https://covid.cdc.gov/covid-data-tracker/#hospitalizations Vaccinations One or more doses, 49,772,180 (15%) Two doses, 24,779,920 (7.5%) Ad26.COV2.S Only single dose vaccine in use https://www.washingtonpost.com/health/2021/02/28/johnson-and-johnson-vaccine-cdc-recommendation/ Centers for Disease Control and Prevention, approves 3rd vaccine for over 18s Food and Drug Administration, Saturday, emergency use Start shipping doses, today 3.9 million doses this week 20 million doses by the end of March Storage / transport Up to two years frozen at –4° F (–20° C) Up to three months refrigerated at 36–46° F (2–8° C). Phase 3, n = 45,000 US agreed to pay Johnson & Johnson $1 billion for 100 million doses if approved EU has ordered 200 million doses COVAX, 500 million doses Hoped for production, 1 billion doses in 2021 November 16, announced 2 dose Phase 3 trial February, started trial for pregnant women Janssen US efficacy data 85% effective at protecting against severe cases 72% effective in preventing moderate illness 100% effective in preventing hospitalization and death after one month Three vaccines, tested at different times, different variants, different levels of transmission Seven deaths in the trial, all in placebo group Saad Omer, Yale Institute of Global Health the more severe the outcome, the more similar the efficacy Chile https://www.emol.com/noticias/Nacional/2021/03/01/1013539/Daza-por-brote-hogar-vacunados.html Outbreak in elderly care facility 40 tested positive No serious illness Three weeks after Sinovac HTTPS://WWW.NYTIMES.COM/INTERACTIVE/2020/SCIENCE/CORONAVIRUS-VACCINE-TRACKER.HTML#SINOVAC CoronaVac Efficacy, 50 - 90% 2 doses, 2 weeks apart, IM, Refrigerated, Inactivated Yet to publish Indonesia, 11th January Turkey, 13th January Brazil, 17th January Billion doses per year India People above 60 Over 45 with certain medical conditions Modi accepts vaccine Czech Republic World’s worst surge in Covid-19 infections Stricter enforced measures Belgium https://www.theguardian.com/world/2021/mar/01/belgium-considers-u-turn-on-oxford-astrazeneca-covid-vaccine-for-over-55s Government to reset vaccination programme People over 55 could be given Oxford/AstraZeneca Scotland, overall 81% reduction in hospital admissions (Belgium, Germany, France, Poland, Italy) Hospital admissions, up 44% on last week Vaccinated, 7% (UK 31%) EU’s 27 member states, 7.26%. European Commission https://www.theguardian.com/world/live/2021/mar/01/coronavirus-live-news-vaccine-acceptance-rising-in-uk-us-and-france-south-africa-eases-restrictions Propose EU-wide digital Covid-19 vaccination passport Allow Europeans to travel more freely over summer digital green pass
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