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No seems to be the simple answer. Observational Study of Hydroxychloroquine in Hospitalized Patients with Covid-19 (NEJM 7th May) https://www.nejm.org/doi/full/10.1056/NEJMoa2012410?query=C19&cid=DM91569_NEJM_Registered_Users_and_InActive&bid=193180241 BACKGROUND Hydroxychloroquine, widely used without robust evidence Anti-inflammatory and antiviral effects Food and Drug Administration, Emergency Use Authorization on March 30, 2020, METHODS Examined the association between hydroxychloroquine use and respiratory failure Association between hydroxychloroquine use and intubation or death New York–Presbyterian Hospital (NYP)–Columbia University Irving Medical Cente 1,446 consecutive patients Tested positive for antigen Compared outcomes, hydroxychloroquine or not Hydroxychloroquine indicated in moderate-to-severe respiratory illness Oxygen saturation of less than 94% on room air RESULTS 1,376 patients followed up for 22.5 days March 7 to April 8, 2020. Follow-up to April 25, 2020 811 (58.9%) received hydroxychloroquine 1,376 respiratory failure developed in 346 patients (25.1%) 180 patients were intubated, and 166 died without intubation No significant association between hydroxychloroquine use and intubation or death CONCLUSIONS Hydroxychloroquine administration was not associated with either a greatly lowered or an increased risk of intubation or death Findings do not support the use of hydroxychloroquine at present, outside randomized clinical trials testing its efficacy Clinical guidance at our medical center has been updated to remove the suggestion that patients with Covid-19 be treated with hydroxychloroquine Were Hydroxychloroquine-treated patients were more severely ill at baseline? Adjusted for likely confounders, Age Race and ethnic group Body-mass index Diabetes Chronic kidney disease Chronic lung disease Hypertension Baseline vital signs Oxygen therapy Inflammatory markers Unmeasured confounding may remain

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