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WHO's Covid report, detailed considered appraisal. https://www.who.int/health-topics/coronavirus/origins-of-the-virus The mission Joint international team, 17 Chinese and 17 international experts 14 January to 10 February 2021 in Wuhan Prevent reinfection, animals and humans Prevent establishment of new zoonotic reservoirs, mink, cats Timeline Outbreak may have started sometime in the months before the middle of December 2019 (Based on molecular sequence data) Circulation of SARS-CoV-2 preceded the initial detection of cases by several weeks. Virus transmission widespread in Wuhan by the first week of 2020 Epidemic in Wuhan preceded the spread in the rest of Hubei Province 174 COVID-19 cases with onset of symptoms in December 2019 8th December 2019, first official case 76,000 ‘cases’ from October and November unlikely Genomics Huanan market, at the point of its closing, 923 environmental samples, 73 samples were positive Widespread contamination of surfaces with SARS-CoV-2 Huanan market cluster had identical virus genomes Other genomes were also discovered from December / January Upstream suppliers to the Huanan market taken during 2020, no evidence of SARS-CoV-2 circulating in animals Initial cases associated with Huanan market, other markets and no markets Coronaviruses most highly related to SARS-CoV-2 found in bats and pangolins None sufficiently similar to SARS-CoV-2 to serve as its direct progenitor Sampling before and after the outbreak 80 000 wildlife, livestock and poultry samples collected, 31 provinces in China No positive result for SARS-CoV-2 antibody or nucleic acid Cold chains Cold chain products, not tested at the time Confirmed international transmission in cold chains Four conclusions Qualitative risk assessment Direct zoonotic spillover is considered to be a possible-to-likely pathway Introduction through an intermediate host is considered to be a likely to very likely pathway Introduction through cold/ food chain products is considered a possible pathway Introduction through a laboratory incident was considered to be an extremely unlikely pathway Next phase Widespread testing of domestic and wild animals Rhinolophus bats, southern provinces of China, countries around East Asia, South-East Asia and any other regions More cold chain analysis Positive results in sewage, serum, human or animal tissues/swab and other SARS-CoV-2 test by the end of 2019 Convene a global expert group https://www.who.int/director-general/speeches/detail/who-director-general-s-remarks-at-the-member-state-briefing-on-the-report-of-the-international-team-studying-the-origins-of-sars-cov-2 https://www.theguardian.com/world/2021/mar/30/who-criticises-chinas-data-sharing-as-it-releases-covid-origins-report US, UK, Australia, Canada, Czechia, Denmark, Estonia, Israel, Japan, Latvia, Lithuania, Norway, Republic of Korea, Slovenia, Statement It is equally essential that we voice our shared concerns that the international expert study on the source of the Sars-Cov-2 virus was significantly delayed and lacked access to complete, original data and samples While regretting the late start of the study, the delayed deployment of the experts and the limited availability of early samples and related data, we consider the work carried out to date and the report released today as a helpful first step EU statement also called on all relevant authorities to help with the next stages So that any gaps in data needed to further the investigation can be addressed Called for timely access for independent experts early in future pandemics Access to China after months of fraught negotiations White House No space for this section in YT comments, descriptions are of limited length. Tedros Adhanom Ghebreyesus In my discussions with the team, they expressed the difficulties they encountered in accessing raw data I expect future collaborative studies to include more timely and comprehensive data sharing Scientists would benefit from full access to data including biological samples from at least September 2019 I concur with the team’s conclusion that farmers, suppliers and their contacts will need to be interviewed Team also visited several laboratories in Wuhan and considered the possibility that the virus entered the human population as a result of a laboratory incident. However, I do not believe that this assessment was extensive enough. Further data and studies will be needed to reach more robust conclusions. Let me say clearly that as far as WHO is concerned all hypotheses remain on the table. Although the team has concluded that a laboratory leak is the least likely hypothesis, this requires further investigation, potentially with additional missions involving specialist experts, which I am ready to deploy This report is a very important beginning, but it is not the end.

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