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Explore Vaccines and genetics with 102,633 views, 3,308 likes, and 1,416 comments. Experience the impact of this video content that has captured audience attention.

Australian vaccine https://www.smh.com.au/politics/federal/australian-covid-vaccine-terminated-due-to-hiv-false-positives-20201210-p56mju.html?utm_source=Nature+Briefing&utm_campaign=dd61a8472e-briefing-dy-20201211&utm_medium=email&utm_term=0_c9dfd39373-dd61a8472e-44762053 University of Queensland Fifty million doses ordered by government 200 volunteers in two groups Aged 18 to 55, and 56 and over, placebo Phase one trial Safe and said it produced a strong immune response Trial terminated; $ 4.5 m (US) lost Several participants, false positive HIV test results No health risks 20 million new doses from Oxford University-AstraZeneca and another 11 million from Novavax US rollout General Gustave Perna Factory, Kalamazoo, Michigan Flight and road -70 degrees Celsius (-94F) First doses of vaccine arriving at 145 sites Monday Tuesday, 425 sites Wednesday, 66 sites Half of 6.4 million doses sent out Pfizer, 50 million in 2020, half to the US US, 100 million doses Approved for 16 years and older Massachusetts-based Moderna, increasing vaccinations to 20 million Americans in 2020 Followed by 200 million Moderna doses Everyone by June 2021 China vaccine Inactivated https://www.bbc.co.uk/news/world-asia-china-55212787 Sinovac, Beijing, CoronaVac Arrived in Indonesia, (Turkey, Brazil, Chile) Another 1.8 m doses due to arrive by January Fridge temperatures Phase 3 results 15th December Production 300 m per year African continent, $2bn Latin American and Caribbean, $1bn Cost? Moderna, 500 million doses in 2021 AstraZeneca, 700 million doses by April UK, Christmas five-day relaxation period https://www.bbc.co.uk/news/uk-wales-55279371 Travel from high to low risk areas Up to three households can stay together, "Christmas bubble" from 23 to 27 December All four UK nations Genetic predisposition https://www.bbc.co.uk/news/health-54832563 Genetic mechanisms of critical illness in Covid-19 Nature, Edinburgh) https://www.nature.com/articles/s41586-020-03065-y Susceptibility to viral infection Propensity to develop harmful pulmonary inflammation. Genetic factors in: Susceptibility to life threatening infections Immune-mediated diseases Host genetic variants Genome-wide association study N = 2, 244 critically ill Covid-19 patients From 208 UK intensive care units Genome-wide significant associations Potential for repurposing of licensed medications Associations with severe COVID Low expression of IFNAR2 (Chromosome 21) Results in lower production of interferon Accounted for nearly 15% of critical Covid-19 cases Interferons interfere with viral replication Produce antiviral enzymes to prevent viral replication Inhibit protein synthesis Stimulate local immune cells Cause fever, muscle aches and general malaise Interferon would need to be given early WHO SOLIDARITY trial https://www.who.int/emergencies/diseases/novel-coronavirus-2019/global-research-on-novel-coronavirus-2019-ncov/solidarity-clinical-trial-for-covid-19-treatments Interferon had little or no effect on overall mortality, initiation of ventilation and duration of hospital stay in hospitalized patients Nebulised interferon beta-1a for patients with COVID-19 (12th November) https://www.thelancet.com/journals/lanres/article/PIIS2213-2600(20)30523-3/fulltext High expression of TYK2 (Chromosome 19) Up regulation of inflammation Rheumatoid arthritis drug, Baricitinib targets this biological mechanism Large-scale randomised clinical trials will be essential

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