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Vaccines 47 vaccines in human trials PFIZER AND BIONTECH ANNOUNCE VACCINE CANDIDATE AGAINST COVID-19 ACHIEVED SUCCESS IN FIRST INTERIM ANALYSIS FROM PHASE 3 STUDY mRNA-based, spike protein vaccine candidate, BNT162b2 https://www.pfizer.com/news/press-release/press-release-detail/pfizer-and-biontech-announce-vaccine-candidate-against First interim efficacy analysis N = 43,538 participants Half vaccine, half placebo Six countries 42% from diverse backgrounds 94 people have caught coronavirus, mostly in the placebo group No serious safety concerns have been observed Safety and additional efficacy data continue to be collected Stored at – 18’C More than 90% effective… Seven days after the second dose in preventing COVID-19… in participants without evidence of prior SARS-CoV-2 infection US approval Submission for Emergency Use Authorization (EUA) to the U.S. Food and Drug Administration (FDA), third week of November UK approval 40 million pre-ordered Apply for UK approval end on this month Could be granted by early December Clinical trial to continue through to final analysis at 164 confirmed cases More information Independent Data Monitoring Committee (DMC) from the Phase 3 clinical study Protection is achieved 28 days after the initiation of the vaccination Expect to produce globally up to 50 million vaccine doses in 2020 Up to 1.3 billion doses in 2021 Plan to submit data from the full Phase 3 trial for scientific peer-review publication Unknowns Prevention of asymptomatic viral shedding Time span of immunity Side effect profile If you would like to donate to this educational project, please use the following link, thank you, https://www.paypal.com/cgi-bin/webscr?cmd=_s-xclick&hosted_button_id=78GGHGLK5ZXAE

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