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Coronavirus, Infection in Children

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Global Cases, 20, 092,855 Deaths, 737, 022 US Cases, 5, 093, 565 Deaths, 163, 473 Cases in Children Autoimmune disorders and other risk factors https://edition.cnn.com/2020/08/11/health/covid-19-children-cases-rising-wellness/index.html https://services.aap.org/en/pages/2019-novel-coronavirus-covid-19-infections/children-and-covid-19-state-level-data-report/ American Academy of Pediatrics (Cumulative Child Cases) Summary of Findings Reported on 8/6/20, accumulative data State health departments of 49 states data 90% increase in cases among children in past four weeks 380,174 total child positive tests 9.1% of all cases 501 cases per 100,000 children in the population 3%-12% of total state tests 3.7%-18.6% tested positive Hospitalizations (20 states and NYC reported) 0.5% -5.3% of total reported hospitalizations 0.3%-8.9% of all child COVID-19 cases resulted in hospitalization Mortality (44 states and NYC reported) 0%-0.4% of all COVID-19 deaths 19 states reported zero child deaths American Academy of Pediatrics Committee on Infectious Diseases (Dr. Sean O'Leary) Cases in children should be taken seriously It's not fair to say that this virus is completely benign in children (Roughly around 100 deaths in children from influenza every year) Factors in increase in children Increased testing Increased movement among children Rise in infection among the general population When you see a lot more infections in the general population, you're going to see a lot more infections in children We all have to take this virus seriously, including taking care of our children Children’s viral load https://jamanetwork.com/journals/jamapediatrics/fullarticle/2768952 JAMA (30th July) Age-Related Differences in Nasopharyngeal Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Levels in Patients With Mild to Moderate Coronavirus Disease 2019 (COVID-19) Mild to moderate illness within 1 week of symptom onset, N = 145 Less than 5 years Young children have equivalent or more viral nucleic acid in their upper respiratory tract compared with older children and adults Ten to 100 times as much viral load 5 – 17 years 18 – 65 years Young children can potentially be important drivers of SARS-CoV-2 spread in the general population As has been demonstrated with respiratory syncytial virus, children with high viral loads are more likely to transmit Behavioral habits of young children and close quarters in school and day care raise concern for SARS-CoV-2 amplification in this population This population will be important for targeting immunization efforts as SARS-CoV-2 vaccines become available. William Haseltine, (former professor at Harvard Medical School) Children ages zero to five can be; highly infectious to other people. It turns out they have a thousand times more virus in their nose than you need to infect, so they're very, very contagious There's every reason to suspect that this virus, even though it can kill you, behaves pretty much like a cold virus, in terms of transmission Who drives colds? Children drive colds And that's true of almost all respiratory diseases, including the colds and including the colds that are caused by coronaviruses And this is one of those cousins It even uses the same receptor in the nasal passages as one of the cold viruses CDC https://www.cdc.gov/mmwr/volumes/69/wr/mm6932e3.htm?s_cid=mm6932e3_w Hospitalization data from 14 states Since March 1, 2020 576 pediatric COVID-19–associated hospitalizations Children, 8.0 per 100,000Adults, 164.5 per 100,000 One in 3 children hospitalised required ICU Brazil Cases, 3, 057, 470 Deaths, 101,752 India Cases, 2, 268, 675 Deaths, 45, 257 Russia Cases, 890, 779 Deaths, 15, 104 South Africa Cases, 563, 598 Deaths, 10,621

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