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EMA recommends COVID-19 Vaccine Janssen for authorisation in the EU https://www.ema.europa.eu/en/news/ema-recommends-covid-19-vaccine-janssen-authorisation-eu Janssen should start delivering vaccines by April, and significant amounts by May https://nos.nl/artikel/2372206-vierde-coronavaccin-goedgekeurd-voor-eu-janssen-krijgt-positief-oordeel.html Recommended conditional marketing authorisation, 18 years + Concluded by consensus that the data on the vaccine were robust and met the criteria for efficacy, safety and quality 4th vaccine now for EU, first single dose Phase 3 N = over 44,000 RCT Half and half 67% reduction in the number of symptomatic cases after 2 weeks US efficacy data 72% effective in preventing moderate illness 85% effective at protecting against severe cases 100% effective in preventing hospitalization and death after one month Side effects Usually mild or moderate Cleared within a couple of days Pain at the injection site, headache, tiredness, muscle pain and nausea Pharmacovigilance will continue UK Ordered 30 million J and J Denmark 14 day halt in use of the Oxford-AstraZeneca vaccine Blood clots, and one death Health Minister Magnus Heunicke precautionary measure we must respond in a timely and careful manner Austria One woman (49) died 10 days after vaccination Estonia, Latvia, Lithuania, Luxemburg have also stopped using the batch EMA Probably 3 cases and one death One million doses in batch Safety committee was reviewing the Austrian case there is currently no indication that vaccination has caused these conditions, which are not listed as side effects with this vaccine thromboembolic events in vaccinated people is no higher than that seen in the general population 22 cases of thromboembolic events, three million people vaccinated with AstraZeneca vaccine in the European Economic Area Authorised 29th January Epidemiology of venous thromboembolism https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4624298/ Incidence rate Men, 130 per 100,000 per year Women, 110 per 100,000 per year That’s 10 per month per 100,000 That’s 120 per million per month Therefore for 3 million of the population 360 thromboembolic events expected per month Czech Republic Sent first patients to Poland Hungary Cases higher than in December Poland Cases highest since late November increased looseness among Poles towards anti-Covid measures Brazil Population 214 million https://www.bbc.co.uk/news/world-latin-america-56355861 Cases, 79,876 Deaths, + 2,000 = 270,656 Second highest death numbers Margareth Dalcolmo, doctor and researcher at Fiocruz the worst moment of the pandemic in Brazil overload and even collapse of health systems Dr Pedro Hallal, Epidemiologist If we do not start vaccinating the population here very soon, it will become a massive tragedy It took a long time for the politicians to act P.1 Could be up to twice as transmittable as the original virus Chance of reinfection, 25% to 60% Brazil, natural laboratory, when coronavirus goes relatively unchecked Breeding ground for new variants, several VOCs circulating Rapid vaccination and NPIs required Vaccines remains efficacious, but probably slight reductions

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