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Explore New research game changer with 278,651 views, 14,229 likes, and 2,705 comments. Experience the impact of this video content that has captured audience attention.

OpenSAFELY https://opensafely.org New secure analytics platform Electronic health records in the NHS Created to deliver urgent results during the COVID-19 emergency Analyses across more than 24 million patients Full pseudonymised primary care NHS records More to follow shortly Open for security review Scientific review Secure environments Trusted analysts Large scale computation Near real-time Analyses in just five weeks from project start. More accuracy than any previous analyses by an order of magnitude Big data Primary care data Sufficient statistical power Associations with specific medications and medical conditions Early during the pandemic Save lives by modifying patient, clinician, and population behaviour Effect of pre-exposure use of hydroxychloroquine on COVID-19 mortality: a population-based cohort study in patients with rheumatoid arthritis or systemic lupus erythematosus using the OpenSAFELY platform Lancet, 5th November, MRC https://www.thelancet.com/journals/lanrhe/article/PIIS2665-9913(20)30378-7/fulltext Hydroxychloroquine Pre¬exposure (as opposed to post¬exposure) prophylactic Inhibit entry of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) into epithelial cells in vitro No evidence of reduced mortality when treating patients with COVID-19 Methods Observational Population-based cohort study Approximately 40% of the general population in England Association between ongoing use before COVID-19 Compared with non-users of hydroxychloroquine Risk of COVID-19 mortality People with rheumatoid arthritis or systemic lupus erythematosus n = 194, 637 with rheumatoid arthritis or systemic lupus erythematosus n = 30, 569 received two or more prescriptions of hydroxychloroquine March 1 and July 13, 2020 547 deaths Users (n= 30,569) 70 deaths IFR = 0.23% Non – users (n = 164,068) IFR = 0.22% An absolute difference of 0·008% Accounting for age, sex, ethnicity, use of other immunosuppressive drugs, and geographical region No association with COVID-19 mortality was observed If you would like to donate to this educational project, please use the following link, thank you, https://www.paypal.com/cgi-bin/webscr?cmd=_s-xclick&hosted_button_id=78GGHGLK5ZXAE

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