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Pirola, BA.2.86. An asteroid that hangs out by Jupiter World Health Organization, BA.2.86 a “variant under monitoring” https://www.gov.uk/government/publications/sars-cov-2-genome-sequence-prevalence-and-growth-rate/sars-cov-2-genome-sequence-prevalence-and-growth-rate-update-30-august-2023 First monitoring 14 August 2023, (horizon scanning) 34 amino acid differences compared with BA.2 https://www.bmj.com/content/382/bmj.p1964 All in spike protein https://www.cdc.gov/respiratory-viruses/whats-new/covid-19-variant.html 36 amino acid changes compared with the 2023 circulating XBB.1.5 This number of genetic differences, is roughly of the same magnitude as seen between the initial Omicron variant (BA.1) and previous variants, such as Delta (B.1.617.2) Declared a variant on 18 August 2023 Week beginning 28 August 2023 2 UK sequences found Denmark, Israel, US, SA, (unlinked) https://www.gov.uk/government/news/flu-and-covid-autumn-vaccine-programmes-brought-forward Precautionary measure taken to protect those most vulnerable from illness during winter following the identification of COVID-19 variant BA.2.86. Vaccinations are now set to start on 11 September 2023 UKHSA suggests speeding up autumn vaccine programme will deliver greater protection, supporting those at greatest risk of severe illness and reducing the potential impact on the NHS. People in care homes for older people, the clinically vulnerable, those aged 65 and over, health and social care staff, and carers. Those who fall into higher-risk groups are being encouraged to take up the jab as soon as they’re invited. Chief Executive of the UK Health Security Agency, Dame Jenny Harries As we continue to live with COVID-19 we expect to see new variants emerge. Thanks to the success of our vaccine programme, we have built strong, broad immune defences against new variants throughout the population. https://www.ama-assn.org/delivering-care/public-health/latest-cdc-fall-covid-variants-new-flu-guidelines-plus-malaria-health A variant that's adept at evading immunity would not necessarily take off in a population if it doesn't spread efficiently. Inherent transmissibility unknown https://www.bmj.com/content/382/bmj.p1964 Transmissibility and severity Little is yet known about the transmissibility of BA.2.86 or whether it may cause more severe disease, but scientists do not expect it to be much different from previous omicron strains currently in circulation. Sore throat 63.41 Runny nose 59.18 Headache 55.84 Blocked nose 54.3 Sneezing 52.5 Cough no phlegm 50.71 Hoarse voice 38.77 Cough with phlegm 38.38 Muscle pains aches 31.58 Fatigue 23.88 Swollen neck glands 20.67 Altered smell 20.54 Dizzy light headed 19.77 Eye soreness 18.1 Earache 15.15 Loss of smell 14.38 Fever 13.61 Joint pain shoulders 13.35 Chest pain tightness 12.84 Shortness of breath 12.84

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