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Nearly all youth in England had COVID-19 antibodies by March 2022. Implications for vaccine policies? https://www.ons.gov.uk/peoplepopulationandcommunity/healthandsocialcare/conditionsanddiseases/articles/coronaviruscovid19/latestinsights 27 June 2022 Results from Round 3 (3rd March to 25th March 2022) Schools Infection Survey Antibodies in secondary school pupils N = 884 99.3% of had SARS-CoV-2 antibodies, comprised of 64.9% who were vaccinated, and 34.4% who were unvaccinated. Antibodies in primary school pupils N = 884 82.0% had SARS-CoV-2 antibodies, comprised of 0.4% who were vaccinated, and 81.6% who were unvaccinated. Schools Infection Survey https://www.ons.gov.uk/releases/covid19schoolsinfectionsurveyenglandpupilantibodydatamarch2022 https://www.ons.gov.uk/peoplepopulationandcommunity/healthandsocialcare/conditionsanddiseases/methodologies/covid19schoolsinfectionsurvey2021to2022methodsandfurtherinformation The pupil antibody test used in Oral fluid collection Lower sensitivity than blood antibody tests, (estimated at 80.0%) for unvaccinated pupils. Immunoglobulins in oral fluids are at least 1 per 1,000th of blood Pupils were tested for Anti-N (antibodies from natural infection), and anti-S (antibodies from natural infection or vaccination) Comparisons between Round 1, Round 2 and Round 3 Round 1 (10th November to 10th December) Primary, 40.1% Secondary, 82.4% Round 2 (10th January to 3rd February) Primary, 62.4% Secondary, 96.6% Round 3, (3rd March to 25th March 2022) Primary, 82% Secondary, 99.3% Antibody testing in Round 3 Coronavirus cases in England were increasing Omicron BA.1 variant times UK infections https://www.ons.gov.uk/peoplepopulationandcommunity/healthandsocialcare/conditionsanddiseases/articles/coronaviruscovid19/latestinsights Week ending 18 June 2022 Likely caused by Omicron variants BA.4 and BA.5. 1,360,600 (1 in 40 people) in England 68,500 (1 in 45 people) in Wales 59,900 (1 in 30 people) in Northern Ireland 250,700 (1 in 20 people) in Scotland Deaths Coronavirus, 6th sixth leading cause of death in England and Wales 3.3% of deaths in both countries In April 2022, COVID-19 was the third leading cause of death. Causes of death, UK https://www.ons.gov.uk/peoplepopulationandcommunity/birthsdeathsandmarriages/deaths/bulletins/monthlymortalityanalysisenglandandwales/february2022 Dementia and Alzheimer’s Ischaemic heart disease Cerebrovascular disease Chronic lower respiratory disease Cancer, trachea, bronchus, lung Influenza and pneumonia Ill-defined conditions Cancer, colorectal Cancer, lymphoid, haemopoietic Deaths in the US https://www.healthline.com/health/leading-causes-of-death Heart disease, 23.1% Cancer, 21.7% Accidents, (unintentional) 5.9% Chronic lower respiratory diseases, 5.6% Stroke, 5.18% Alzheimer’s 4.23% Diabetes, 2.9% Influenza and pneumonia, 1.88% Kidney disease, 1.8% Suicide, 1.64% Septicemia, 1.42% Chronic liver disease and cirrhosis, 1.39%

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