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BMJ references in this video relating to 'Covid-19: Do many people have pre-existing immunity' are based on a rapid response letter NOT to an empirical paper. 16th September, Vitamin D and pandemic science https://www.youtube.com/watch?v=ZqZLMoLvhgk 12th September, Vitamin D, Large scale studies https://www.youtube.com/watch?v=iNji13yoW9g 6th September, Vitamin D, Frist clinical trial https://www.youtube.com/watch?v=V8Ks9fUh2k8 27th July, Vitamin D, Science https://www.youtube.com/watch?v=cv4iINxf4IM 20th June, Vitamin D hits the media https://www.youtube.com/watch?v=qyMFsLFAE5o 10th June, Vitamin D update https://www.youtube.com/watch?v=_fIMkigtnk4 18th May, Dr Shelton, Part 1, Reports from New Zealand https://www.youtube.com/watch?v=pRd7TqqIxzg&t=1s 21st May, Dr Shelton, Part 2, Vitamin D https://www.youtube.com/watch?v=JVg8opQkQXc 10th May, Vitamin D dose https://www.youtube.com/watch?v=Bga_qG30JyY 15th April, Vitamin D and Immunity, Lots of evidence https://www.youtube.com/watch?v=GCSXNGc7pfs 9th March, Vitamin D and immunity https://www.youtube.com/watch?v=W5yVGmfivAk Correcting Britain's Vitamin D deficiency could save thousands of lives (David Davis MP, Matt Ridley) https://www.telegraph.co.uk/news/2020/09/26/correcting-britains-vitamin-d-deficiency-could-save-thousands/ There is one chemical that: is known to be safe known to be needed by many people anyway known to have a clinically proven track record of helping people fight off respiratory diseases is so cheap no big firm is pushing it vitamin D Vitamin D Levels Appear to Play Role in COVID-19 Mortality Rates https://www.mccormick.northwestern.edu/news/articles/2020/05/vitamin-d-levels-appear-to-play-role-in-covid-19-mortality-rates.html https://www.medrxiv.org/content/10.1101/2020.04.08.20058578v4 China, France, Germany, Italy, Iran, South Korea, Spain, Switzerland, the United Kingdom, United States. Patients with severe deficiency are twice as likely to experience major complications Spanish clinical trial https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7456194/ Calcifediol group, 2% required admission to the ICU Control group 50% admitted to ICU Put another way, the use of Vitamin D reduced a patient’s risk of needing intensive care 25-fold The Government should now act on this latest evidence We have good reason to think vitamin D supplementation will help reduce mortality from Covid-19 we know it can reduce the incidence and severity of the other acute respiratory illnesses pressures from influenza during the winter months This will no doubt save thousands of lives in any second wave There is now no reason not to act Covid-19: Do many people have pre-existing immunity? (21 September 2020, Eshani M King, BMJ) https://www.bmj.com/content/370/bmj.m3563/rr-6 Many have T cells that act against SARS-CoV-2 epitopes Killing intracellular parasites Critical in viral immunity T cell response might be more important that B cell response https://onlinelibrary.wiley.com/doi/full/10.1111/pai.13263 B‐cell response might be important, but is not strictly required to overcome the disease Vaccines focused on antibody levels Mild or asymptomatic cases, many T-cells are produced In these mild cases, few or no detectable antibodies Men produced fewer T-cells than women Older men produce less T cells than younger men Vitamin D controls T cell antigen receptor signaling and activation of human T cells, (University of Copenhagen) https://pubmed.ncbi.nlm.nih.gov/20208539/ Vitamin D essential to facilitate maturation of naïve T cells to dedicated, specific T cells When a T cell is exposed to a foreign pathogen, it extends a vitamin D receptor, with which it searches for vitamin D If there is an inadequate vitamin D level, they won't even begin to mobilize Also Physical mucosal defences All other immune cells Modulating cytokines Problems https://osf.io/preprints/nutrixiv/73whx/ Obesity Diabetes BAME Male Elderly City dwellers Japan Low death rate Active elderly Vitamin D levels of over 30 ng/ml (75 nmol/l) in 95% UK average levels are below 20ng/ml (50 nmol/l) The Role of Vitamin D deficiency in COVID-19 related deaths in BAME, Obese and Other High-risk Categories https://osf.io/preprints/nutrixiv/73whx/ To convert ng/ml of 25(OH)D to nmol/l the conversion factor is 2.5. 20ng/ml enough to prevent rickets, osteoporosis and osteomalacia 40-60ng/ml or more is required to achieve optimum immune system and cancer fighting capability 30 ng/ml being sufficient but not optimal 40-60ng/ml Maasai IU mcg 400 10mcg 800 20mcg 1,000 25mcg 2,000 50mcg 4,000 100mcg 6,000 150mcg

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