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New Zealand Ruled out Frozen food items or freight Burning ember Infection from returners https://www.health.govt.nz/our-work/diseases-and-conditions/covid-19-novel-coronavirus/covid-19-current-situation/covid-19-current-cases Cases, + 13 + 7 + 13 + 9 + 12 = 1643 Hospitalised, + 1 = 6 Long term immunity It would be good if, Antibodies provide “real-world” protection Cellular immunity is long-lasting Memory B and T lymphocytes T helpers, suppressors, killers (cytotoxic) Even in mild cases. New Delhi 24% Mumbai 24% Moscow 21.7 % Stockholm 10 % New York 6.9 % London 17.5 % UK 6.2 % Marion Pepper, immunologist, University of Washington This is exactly what you would hope for All the pieces are there to have a totally protective immune response Smita Iyer, immunologist, University of California, Davis This is very promising This calls for some optimism about herd immunity, and potentially a vaccine Professor Danny Altmann, Department of Immunology and Inflammation, Hammersmith Hospital, Imperial College While this is a small study, it offers a remarkable, real-life, human experiment at a time when we've been short of hard-line, formal, proof that neutralising antibodies genuinely offer protection from re-infection In short, it’s good news https://www.telegraph.co.uk/global-health/science-and-disease/optimism-covid-19-immunity-climbs-studies-show-antibodies-protect/ Neutralizing antibodies correlate with protection from SARS-CoV-2 in humans during a fishery vessel outbreak with high attack rate https://www.medrxiv.org/content/10.1101/2020.08.13.20173161v1 University of Washington IRB Identification of immunological correlates would help research Only animal models to date Outbreak of SARS-CoV-2 on a fishing boat Attack rate on board of 85.2% (104/122 individuals) Predeparture serological and viral RT-PCR testing Repeat testing after return to shore Full data on 120 of the 122 crew (9 women) 18 day trip, crew member required hospitalization Median follow-up of 32.5 days 104 individuals had a positive antigen test or seroconverted during the follow-up period 101 developed IgG antibodies within 50 days Also Three crew members seropositive prior to the boat's departure None of these crew members with antibodies developed symptoms or tested antigen positive Lab studies also showed their antibodies had neutralising activity Presence of neutralizing antibodies from prior infection was significantly associated with protection against re-infection (p=0.002). Robust T cell immunity in convalescent individuals with asymptomatic or mild COVID-19 Center for Infectious Medicine, Stockholm https://www.biorxiv.org/content/10.1101/2020.06.29.174888v1 Virus-specific memory T cells have been shown to persist for many years after infection with SARS-CoV-1 Acute phase SARS-CoV-2-specific T cells display high cytotoxic activity Correlated with various clinical markers of disease severity SARS-CoV-2-specific T cells were detectable in antibody-seronegative family members and individuals with a history of asymptomatic or mild COVID-19 Collective dataset shows that SARS-CoV-2 elicits robust memory T cell responses akin to those observed in the context of successful vaccines natural exposure or infection may prevent recurrent episodes of severe COVID-19 also in seronegative individuals. SARS-CoV-2 induces robust memory T cell responses in antibody-seronegative and antibody-seropositive individuals with asymptomatic or mild COVID-19. Functional SARS-CoV-2-specific immune memory persists after mild COVID-19 https://www.medrxiv.org/content/10.1101/2020.08.11.20171843v2 Study was approved by the University of Washington Institutional Review Board The recently emerged SARS-CoV-2 virus is currently causing a global pandemic and cases continue to rise. The majority of infected individuals experience mildly symptomatic disease but it is unknown whether this can induce persistent immune memory that might contribute to herd immunity Longitudinal assessment Individuals recovered from mildly symptomatic COVID-19 To determine if they develop and sustain immunological memory Recovered individuals developed SARS-CoV-2-specific IgG antibody As well as virus-specific memory B and T cells In some cases increased numerically over three months following symptom onset Memory lymphocytes exhibited characteristics associated with potent antiviral immunity Memory T cells secreted IFN-γ (interferon Gama) and expanded upon antigen re-encounter Memory B cells expressed specific antibodies

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