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Timeline https://docs.google.com/document/d/170pf3dN8qYGisVIWM4cDpFwHCO63FJtfhQbuiTrKM6k/edit?usp=sharing https://www.telegraph.co.uk/global-health/science-and-disease/doubts-oxford-vaccine-fails-stop-coronavirus-animal-trials/?fbclid=IwAR2kmCw4KaLZZCIwpcabRxbIAP7rLS85LDZ1orhUJuxkyFhgPHTs6O8r1jQ Oxford AZ vaccine ‘All of the 6 vaccinated monkeys treated with the Oxford vaccine became infected when challenged’ ‘That viral loads in the noses of vaccinated and unvaccinated animals were identical’ Less severe clinical symptoms than unvaccinated animals Neutralising antibody titres were low, insufficient to prevent infection Insufficient to prevent viral shedding in nasal secretions Human trials began in April with a non-vaccinated control group 2 groups now undergoing antibody studies Results in a few months Now preparing for 30,000 subjects, including elderly and children New vaccines risk antibody-induced enhancement This effect caused serious lung damage in animals given experimental vaccines for both SARS-1 and MERS. Beth Israel Deaconess Medical Center, immunity and vaccine https://www.eurekalert.org/pub_releases/2020-05/bidm-bvp051920.php https://www.bostonglobe.com/2020/05/20/nation/two-studies-suggest-that-covid-19-antibodies-provide-immunity/ Two studies, Infection prevents reinfection. Prototype vaccines protected against SARS-CoV-2 Antibodies do provide protection, whether they are triggered by an infection or a vaccine. Study 1 Researchers infected 9 adult monkeys, noses and lungs Virus quickly spread into their upper and lower respiratory tracts All 9 developed viral pneumonia All recovered within 28 days. A week later, re-exposed, none of the animals got sick Immunity passports Study 2 35 monkeys 25 vaccinated (2 doses), 10 not vaccinated One of six prototypes of DNA vaccines All prototype vaccines used the genetic code for portions of the protein that CoV-2 uses to invade cells All of the vaccinated monkeys developed antibodies, some at recovered monkey level 6 candidate DNA vaccines induced neutralizing antibody 3 weeks after the second vaccine dose, All monkeys inoculated with COVID-19 25 vaccinated and 10 not vaccinated None of the vaccinated monkeys developed high levels of the virus in their lungs All 10 of the unvaccinated monkeys did 8 of the 25 vaccinated demonstrated no detectable virus at any point 17 monkeys showed low levels of virus Higher antibody levels were linked to lower viral loads Therefore, lab test for risk of infection can be developed Questions Does this all apply to humans? How long will the naturally or vaccine acquired immunity last?

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