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Antivirals in Japan Ivermectin allowed as a treatment on August 13 Doctors can prescribe without restrictions People can buy it legally from India Dr. Haruo Ozaki, Chairman of the Tokyo Medical Association https://www.tokyo-np.co.jp/article/123988 The situation is that the whole country is suffering from disasters. No one will listen to me, so I will come up with a new policy The antiparasitic drug "ivermectin" shows the number of infections and deaths of the new corona in a country that is prophylactically administered for another disease in Africa. It is necessary to thoroughly study the clinical trial, but it seems that we are at the stage where it is okay to have the patient give an informed outlet and get permission to use it Japan https://www.japantimes.co.jp/news/2021/11/22/national/japan-coronavirus-november22/ Population, 126 million Cases, + 79 Deaths, + 2 Lowest since June 23, 2020 Currently reopening More than 76% of population is fully vaccinated (South Korea, high vaccination but uptick in infections) Boosters to start in December Ingrained pre-pandemic flu seasons mask wearing Delta variant wave ends Delta variant “self-extinction” Viral genetic mutations Ituro Inoue, professor, National Institute of Genetics Delta variant in Japan accumulated too many mutations Virus’s error-correcting protein, nsp14 Majority of nsp14 specimens in Japan seemed to have undergone many genetic changes in mutation sites called A394V Non-structural protein, made by the virus Therefore errors accumulated leading to non-viability Also More people in Asia have a defense enzyme called APOBEC3A that attacks RNA viruses, Including the SARS-CoV-2 virus that causes COVID-19, when compared to people in Europe and Africa. National Institute of Genetics and Niigata University Research to discover how the APOBEC3A protein affects the nsp14 protein A394V discovered in 24 other countries SARS ended abruptly in 2003 Working on a drug to inhibit nsp14

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