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Moderna boosters, recommended by FDA independent advisory panel 65 and older and for adults who are at high risk of severe illness Six months Half dose Jacqueline Miller, head of Moderna’s infectious-disease therapeutic area https://www.washingtonpost.com/health/2021/10/14/moderna-booster-shot-fda/ Six to eight months after vaccination, antibody levels dropped in vaccine recipients. A half-dose booster at least six months after initial vaccination restored antibodies levels People from original trial, a clear uptick in breakthrough infections this July and August UK ONS https://www.ons.gov.uk/peoplepopulationandcommunity/healthandsocialcare/conditionsanddiseases/articles/coronaviruscovid19/latestinsights#cis Week ending 9 October 2021 People that that had COVID-19 in the week Up in England, Wales and NI Down in Scotland 1.63% in England (1 in 60 people) 2.18% in Wales (1 in 45 people) 0.82% in Northern Ireland (1 in 120 people) 1.26% in Scotland (1 in 80 people) People testing positive for antibodies 93.6% Mortality displacement did not offset excess deaths by mid-2021 Some evidence of mortality displacement during the pandemic Mortality displacement, when vulnerable people die sooner than expected Potentially leading to a lower-than-average period of mortality These periods of below average mortality did not offset the high number of deaths since the beginning of the pandemic 3 January 2020 to 2 July 2021 97,981 excess deaths in England and Wales (compared to what we would expect in a non-pandemic period). Within 28 days of a positive test, 138,379 Certificated, 161,798 Zoe data https://covid.joinzoe.com/data#levels-over-time https://covid.joinzoe.com/post/third-wave-reaches-new-peak Long covid https://www.ons.gov.uk/peoplepopulationandcommunity/healthandsocialcare/conditionsanddiseases/articles/coronaviruscovid19/latestinsights#cis Long covid as of 5 September 2021 An estimated 1.1 million in the UK experiencing long COVID https://www.ons.gov.uk/peoplepopulationandcommunity/healthandsocialcare/conditionsanddiseases/articles/coronaviruscovid19/latestinsights#cis 1.7% of the total population were experiencing self-reported long COVID Up from 970,000 (1.5%) at 1 August 2021 831,000 (77%) first had (or suspected they had) COVID-19 at least 12 weeks previously 405,000 (37%) first had (or suspected they had) COVID-19 at least one year previously Symptoms adversely affected the day-to-day activities of around two-thirds (65%) of those with self-reported long COVID Fatigue (56%) Shortness of breath (40%) Loss of smell (32%) Difficulty concentrating (31%) Professor Tim Spector The UK seems to be slowly waking up to the fact that COVID cases are too high, but the reality is they’ve been soaring for months and many countries have put us on their red list. Infections remain high in young people, and look to be spilling over into the 35-55 year olds. If these increases creep into the over 55s it could spell disaster for the NHS this winter. Herd immunity https://www.youtube.com/watch?v=eJHdFOwZjVI Minimum 85% With cases so high, it’s clear that herd immunity isn't happening Current symptoms in vaccinated and children Runny nose, 76% Headache, 75% Sneezing, 66% Sore throat, 53% Cough 53% Loss of smell or taste UK official data https://coronavirus.data.gov.uk

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