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Explore Long term COVID with 155,715 views, 5,106 likes, and 1,734 comments. Experience the impact of this video content that has captured audience attention.

Long-term Health Consequences of COVID-19 (JAMA, 5th October) https://www.telegraph.co.uk/global-health/science-and-disease/long-covid-can-really-grim-rarer-think/ Ongoing symptoms to substantial end-organ dysfunction https://jamanetwork.com/journals/jama/fullarticle/2771581?guestAccessKey=6c60fb00-1424-47b5-abc9-0b502a194f46&utm_source=silverchair&utm_medium=email&utm_campaign=article_alert-jama&utm_content=olf&utm_term=100520 Post-Acute COVID Persistent severe symptoms, beyond 3 weeks Chronic COVID-19 Beyond 12 weeks Common complaints https://www.bbc.co.uk/news/health-54296223 Crippling fatigue Breathlessness Persistent cough Joint pain Muscle aches Chest pain Hearing and eyesight problems Headaches Loss of smell and taste Damage to the heart, lungs, kidneys and gut Depression Anxiety Struggling to think clearly Not directly related to severity of acute phase Some cases may be related to pneumonia Symptom Duration and Risk Factors for Delayed Return to Usual Health Among Outpatients with COVID-19 https://pubmed.ncbi.nlm.nih.gov/32730238/ US CDC Random sample of 292 adults who had tested positive 35% of 274 symptomatic respondents, not returned to usual health 14 – 16 days after testing 18 – 34 year olds N = 85, 26%. (74% returned to normal) 35-49 years N = 96, 32% (68% returned to normal) 50 and older N = 89, 47% (53% returned to normal) Post–intensive care syndrome 6 – 12 months, cognitive, mental health, physical function Persistent Symptoms in Patients After Acute COVID-19 (JAMA, July 2020, Rome) https://jamanetwork.com/journals/jama/fullarticle/2768351 143 patients discharged from the hospital 18 patients (12.6%) were completely free of any COVID-19–related symptoms after a mean of 60 days Therefore 87.4 not returned to full normal Manifestations None of the patients had fever or any signs or symptoms of acute illness Worsened quality of life, 44.1% Pathogenesis Direct tissue invasion by the virus The virus cleares from most of the body, but lingers in some small pockets If there's long-term diarrhoea then you find the virus in the gut, if there's loss of smell it is in the nerves - so that could be what's causing the problem (Tim Spector) Metabolic effects New-Onset Diabetes in Covid-19 https://www.nejm.org/doi/full/10.1056/NEJMc2018688 COVID induced diabetes Profound inflammation and cytokine storm Immune system does not return to normal https://www.immunology.org/sites/default/files/BSI_Briefing_Note_August_2020_FINAL.pdf Ongoing immunological effects Organ damage Seen in MERS and SARS https://www.medicaljournals.se/jrm/content/abstract/10.2340/16501977-2694 Lung function abnormalities Psychological impairment Reduced exercise capacity Brain alterations Cerebral Micro-Structural Changes in COVID-19 Patients. An MRI-based 3-month Follow-up Study https://www.thelancet.com/journals/eclinm/article/PIIS2589-5370(20)30228-5/fulltext Hypercoagulable state Blood vessel damage https://www.bbc.co.uk/news/health-54296223 Possible inflammation of coronary arteries The Post-hospitalisation COVID-19 study (PHOSP-COVID) https://www.phosp.org https://www.youtube.com/watch?v=IiOpm_UAjgI&feature=emb_logo MRC study under Professor Chris Brightling Following up 10, 000 people post COVID Develop trials of new strategies for clinical care

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