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Illness duration and symptom profile in symptomatic UK school-aged children tested for SARS-CoV-2 https://www.thelancet.com/journals/lanchi/article/PIIS2352-4642(21)00198-X/fulltext PDF https://www.thelancet.com/action/showPdf?pii=S2352-4642%2821%2900198-X https://www.bbc.co.uk/news/health-58071898 Background Infection is usually asymptomatic or causes a mild illness of short duration Persistent illness has been reported To determine illness duration and characteristics in symptomatic UK school-aged children COVID Symptom Study Methods Prospective cohort study Aged children 5–17 years Reported by an adult proxy Illness duration and symptom prevalence, for children testing positive Data from symptomatic children testing negative for SARS-CoV-2, matched 1:1 for age, gender, and week of testing, were also assessed Findings, Children aged 5–17 March 24, 2020 to Feb 22, 2021 N = 258,790 Valid test result, n = 75,529 had valid test results for SARS-CoV-2. Positive test result, n = 1,734 children (588 younger and 1,146 older children) And had a calculable illness duration The most common symptoms Headache 1,079 (62·2%) of 1734 children Fatigue 954 (55·0%) of 1734 children) Median illness duration Children testing positive, 6 days Children testing negative, 3 days Illness duration associated with age (Spearman's rank-order rs 0·19, p less than 0·0001) Median illness duration was longer for older children Older children, 12 to 17 years, 7 days Younger children, 5 to 11 years, 5 days Illness duration of at least 28 days 77 (4·4%) of 1,734 children 59 (5·1%) of 1,146 older children 18 (3·1%) of 588 younger children (p=0·046) After day 28, median 2 symptoms First week of illness, median 6 symptoms Commonest symptoms, first 4 weeks of illness Fatigue 65 (84·4%) of 77 Headache 60 (77·9%) of 77 Anosmia 60 (77·9%) of 77 Symptoms for at least 56 25 (1·8%) of 1379 children Interpretation COVID-19 in children is usually of short duration with low symptom burden Some children with COVID-19 experience prolonged illness duration Symptom burden did not increase with time Most recovered by day 56
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