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Get Surfshark VPN at https://surfshark.deals/minuteearth and enter code MINUTEEARTH for 83% off and 3 extra months free! The body can get a whole lot colder - but not a whole lot hotter - before we die. Why is that? LEARN MORE ************** To learn more about this topic, start your googling with these keywords: Hyperthermia: a medical condition where an individual's body temperature is elevated beyond normal Hypothermia: a medical doncition that occurs when an individual's body loses heat faster than it can produce heat, causing a dangerously low body temperature Thermoregulation is the ability of an organism to keep its body temperature within certain boundaries, even when the surrounding temperature is very different Denaturation: the alteration of a protein shape through some form of external stress (for example, heat), so that it can no longer carry out its cellular function If you liked this week’s video, you might also like: A great article from Outside on hyperthermia: https://www.outsideonline.com/2398105/heat-stroke-signs-symptoms Learn more about the woman who survived the lowest known body temp: https://www.atlasobscura.com/articles/the-woman-who-survived-the-lowest-body-temperature-ever SUPPORT MINUTEEARTH ************************** If you like what we do, you can help us!: - Become our patron: https://patreon.com/MinuteEarth - Share this video with your friends and family - Leave us a comment (we read them!) CREDITS ********* Kate Yoshida | Script Writer, Narrator and Director Sarah Berman | Illustration, Video Editing and Animation Nathaniel Schroeder | Music MinuteEarth is produced by Neptune Studios LLC https://neptunestudios.info OUR STAFF ************ Sarah Berman • Arcadi Garcia Rius David Goldenberg • Julián Gustavo Gómez Melissa Hayes • Alex Reich • Henry Reich Peter Reich • Ever Salazar • Kate Yoshida OUR LINKS ************ Youtube | https://youtube.com/MinuteEarth TikTok | https://tiktok.com/@minuteearth Twitter | https://twitter.com/MinuteEarth Instagram | https://instagram.com/minute_earth Facebook | https://facebook.com/Minuteearth Website | https://minuteearth.com Apple Podcasts| https://podcasts.apple.com/us/podcast/minuteearth/id649211176 REFERENCES ************** Lepock JR (2004). Role of nuclear protein denaturation and aggregation in thermal radiosensitization, International Journal of Hyperthermia, 20:2, 115-130, https://www.tandfonline.com/doi/abs/10.1080/02656730310001637334 Leuenberger, P, Ganscha S, Kahraman A, Cappelletti V, PJ Boersema, Mering Cv, Claassen M, Picotti P (2017). Cell-wide analysis of protein thermal unfolding reveals determinants of thermostability Science, 355: eaai7825. https://science.sciencemag.org/content/355/6327/eaai7825 Roti Roti J (2008) Cellular responses to hyperthermia (40–46 degrees C): cell killing and molecular events. International Journal of Hyperthermia 24(1): 3–15. https://www.tandfonline.com/doi/full/10.1080/02656730701769841 Sawka MN, Leon LR, Montain SJ, Sonna LA (2011). Integrated physiological mechanisms of exercise performance, adaptation, and maladaptation to heat stress. Comprehensive Physiology 1: 1883-1928. https://onlinelibrary.wiley.com/doi/abs/10.1002/cphy.c100082 Slovis CM, Anderson GF, Casolaro A (1982). Survival in a heat stroke victim with a core temperature in excess of 46.5 C. Annals of Emergency Medicine 11(5):269-271. https://linkinghub.elsevier.com/retrieve/pii/S0196-0644(82)80099-1

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