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Puluhan tahun lalu, ada dua ilmuwan yang mau ngejawab satu pertanyaan terbesar umat manusia: apakah kehidupan bisa muncul dari benda mati? Mereka bikin sup purba yang terdiri dari benda-benda mati. Tapi ternyata, dari sana bisa muncul bahan dasar penyusun sel! Temuan ini jadi potongan penting buat nyusun puzzle tentang asal-usul kehidupan. Tapiii waktu ilmuwan lain ngulangin resep yang sama, mereka malah nemuin sesuatu yang lebih gila. “Nenek moyang” semua sel makhluk hidup di Bumi. Protosel. Apakah itu? Enjoy the video! --- Gabung jadi member Kok Bisa untuk dukung kami secara langsung! https://www.youtube.com/channel/UCu0yQD7NFMyLu_-TmKa4Hqg/join Tanyakan pertanyaan aneh anda di sini! NGGA ada pertanyaan yang bodoh! 'Kok Bisa' ngga cuma sekedar mencoba menjawab pertanyaan-pertanyaan yang terlihat bodoh, aneh dan dungu di sini, tapi juga mencoba menumbuhkan rasa keingintahuan anda terhadap segala hal di dunia ini. Jadi, tunggu apalagi? Ayo subscribe, let's watch the videos and go curiosity! --- For business inquiries: [email protected] --- References: Britannica. (n.d.). Miller-Urey experiment. Encyclopedia Britannica. https://www.britannica.com/science/Miller-Urey-experiment El País. (2024, December 31). Protocells emerge in experiment simulating lifeless world: “There is no divine breath of life”. https://english.elpais.com/science-tech/2024-12-31/protocells-emerge-in-experiment-simulating-lifeless-world-there-is-no-divine-breath-of-life.html Frenkel-Pinter, M., Haynes, J. W., Mohyeldin, A. M., Jin, L., Chun, J., Duffy, C. D., ... & Hud, N. V. (2018). Selective incorporation of proteinaceous over nonproteinaceous cationic amino acids in model prebiotic oligomerization reactions. Origins of Life and Evolution of Biospheres, 48(4), 391–412. https://doi.org/10.1007/s11084-018-9554-x Garcia-Ruiz, J. M., Moreno, A., Rull, F., & Gómez-Moreno, C. (2024). From silicone to protocells: Crystallization-driven origins of life. Proceedings of the National Academy of Sciences, 121(8), e2413816122. https://doi.org/10.1073/pnas.2413816122 Green, D. W., Watson, J. A., Ben-Nissan, B., Watson, G. S., & Stamboulis, A. (2021). Synthetic tissue engineering with smart, cytomimetic protocells. Biomaterials, 276, 120941. https://doi.org/10.1016/j.biomaterials.2021.120941 Hanczyc, M. M. (2018). Protocells. In Biochemistry, Genetics and Molecular Biology Topics. ScienceDirect. https://www.sciencedirect.com/topics/biochemistry-genetics-and-molecular-biology/protocell Lang, S. Q., & Bernhardt, H. S. (2018). The emergence of life from iron-sulfur chemistry: Four key steps. Trends in Microbiology, 26(10), 858–870. https://doi.org/10.1016/j.tim.2018.03.003 Liu, D., Wang, Z., Jiang, X., et al. (2024). Prebiotic peptide formation triggered by CO₂ fixation within self-assembled iron-sulfur peptide protocells. Proceedings of the National Academy of Sciences, 121(31), e2413816122. https://doi.org/10.1073/pnas.2413816122 Luisi, P. L. (2018). Chemical aspects of synthetic biology. Current Opinion in Systems Biology, 1, 130–136. https://doi.org/10.1016/j.coisb.2017.11.005 Max Planck Society. (2019, January 10). The origin of life in membraneless protocells. https://www.mpg.de/12325961/1008-mozg-112489-the-origin-of-life-in-membraneless-protocells Miller, S. L. (1953). A production of amino acids under possible primitive Earth conditions. Science, 117(3046), 528–529. https://doi.org/10.1126/science.117.3046.528 Nunes Palmeira, R., Egas, C., & Rocha, M. (2018). Synthetic protocell biology: From reproduction to computation. Trends in Biotechnology, 36(9), 914–929. https://doi.org/10.1016/j.tibtech.2018.03.011 Oparin, A. I. (1957). The origin of life on the Earth (3rd ed.). Academic Press. Oro, J. (2021). The role of borosilicate glass in Miller-Urey experiment. ResearchGate. https://www.researchgate.net/publication/355585039_The_role_of_borosilicate_glass_in_Miller-Urey_experiment PNAS. (2024, July 29). Functional RNAs spontaneously emerge from random RNA sequences in simulated prebiotic conditions. Proceedings of the National Academy of Sciences of the United States of America. https://doi.org/10.1073/pnas.2413816122 Professor Dave Explains. (2023, October 11). The origin of life: From chemistry to protocells [Video]. YouTube. https://www.youtube.com/watch?v=TK1E3heBSiI ScienceDirect. (n.d.). Protocell. In Topics in Biochemistry, Genetics and Molecular Biology. https://www.sciencedirect.com/topics/biochemistry-genetics-and-molecular-biology/protocell Urey, H. C., & Miller, S. L. (1953). Production of amino acids under possible primitive Earth conditions. Science, 117(3046), 528–529. https://doi.org/10.1126/science.117.3046.528 --- A massive THANK YOU to everyone for watching this and for all of your support!
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