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Explore Tuesday 5th May, Stroke and Vit D with 261,085 views, 8,518 likes, and 1,990 comments. Experience the impact of this video content that has captured audience attention.

Large-Vessel Stroke as a Presenting Feature of Covid-19 in the Young (NEJM 28th April) https://www.nejm.org/doi/full/10.1056/NEJMc2009787?query=recirc_mostViewed_railB_article 5 cases reported from NYC area in under 50s 1 woman, 4 men Large vessel ischaemic stroke SARS-CoV-2 infection was diagnosed in all five Patient 1 33-year-old woman, previously healthy Cough, headache, and chills lasting 1 week Progressive dysarthria Numbness and weakness in the left arm and left leg over 28 hours Right middle cerebral artery COVID lung involvement Antiplatelet therapy then anticoagulation therapy. Repeat CT angiography on hospital day 10 showed complete resolution of the thrombus Discharged to rehabilitation By comparison, every 2 weeks over the previous 12 months, our service has treated, on average, 0.73 patients younger than 50 years of age with large-vessel stroke. Wuhan, incidence of stroke among hospitalized patients with Covid-19 was approximately 5%, (youngest 55) Large-vessel stroke was reported, 2004 SARS-CoV-1, Singapore Coagulopathy and vascular endothelial dysfunction have been proposed as complications of Covid-19. The association between large-vessel stroke and Covid-19 in young patients requires further investigation. Two patients in our series delayed calling an ambulance because they were concerned about going to a hospital during the pandemic. Vit D in Indonesia https://papers.ssrn.com/sol3/papers.cfm?abstract_id=3585561#.XqWfqZvYqW0.twitter Patterns of COVID-19 Mortality and Vitamin D: An Indonesian Study (26th April) Retrospective cohort study which included two cohorts (active and expired) of 780 cases with laboratory-confirmed infection of SARS-CoV-2 in Indonesia Age, sex, co-morbidity, Vitamin D status, and disease outcome (mortality) were recorded Serum 25(OH) D levels 1. Normal, greater than 30 ng/ml 2. Insufficient, 21-29 ng/ml 3. Deficient, less than 20 ng/ml. This Results Death risk factors, male, increasing age, pre-existing condition, below normal Vitamin D serum level When controlling for age, sex, and comorbidity, Vitamin D status is strongly associated with COVID-19 mortality outcome of cases. When compared to cases with normal Vitamin D status, death was approximately 10.12 times more likely for Vitamin D deficient cases (OR=10.12; p less than 0.001).

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