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Current antibody studies to SARS-CoV-2 https://www.bmj.com/content/370/bmj.m3563.full 23% in New York 18% in London 11% in Madrid General population, substantially lower Many national surveys reporting in single digits Mike Ryan, a long way to burn UK PM, second wave inevitable, coming in now One in five people in the UK, subject to local lockdown Matt Hancock, the number of people in hospital is doubling every eight days or so ... we will do what it takes to keep people safe https://coronavirus.data.gov.uk/healthcare London new year fireworks cancelled Moonshot Legal action £100bn 10m tests per day Involves potentially huge private contracts that may not have been tendered Breaks the government’s own value-for-money rules Ireland Dublin Taoiseach Micheál Martin, the threat is growing Cases, 104 per 100,000 National rate of 53 Cases, x 10 in past month It comes from community transmission and we need to keep it out of homes in the first place New restrictions on gatherings, businesses and travel Level 2 to Level 3 on a five-level scale of restrictions Netherlands Regional measures Cases, + 1,972 Record number of cases for the fourth consecutive day France Cases, + 13,215 New infections down by 8% from last week Likely an underestimate due to saturation of testing capacity in certain regions May contribute to spread Deaths, + 129 + 256 (week) = 31,249 Highest daily toll the highest in four months Affected regions and cities in France have tightened regulations Nice, Marseille, Bordeaux, Paris Infections now growing fast among the over-75s Hospital and ICU admissions rising Greece Cases, + 359 + 339 = 14,738 People coming back from holidays Mandatory use of masks in all closed public and private spaces Cases, half in Athens Athens Cases increasing Monday, 9 people outdoors, 20 people attend funerals, weddings and baptisms Indoor and outdoor concerts have been suspended People over 68, curtail their movements and avoid public transport Employers, ensure 40% of office work is done from home Spain Cases, + 14,389 = 640,040 More than a third of the new cases were in the Madrid region. Madrid Current epicentre Partial lockdown of some districts Involving 37 worst hit areas from Monday. Areas where there are more than 1,000 cases per 100,00 New measures affect 850,000 people Zones closed off except for work, educational, legal or medical needs Rule of 6 Public and private gatherings will be limited to six people and parks will be closed. US Cases, 6, 724, 667 Deaths, 197, 116 https://covid.cdc.gov/covid-data-tracker/#cases_casesinlast7days Surgeon General, Jerome M. Adams February 29th, you may be increasing your chances of getting a disease by wearing that mask Dr. Ashish Jha (Dean, Brown University School of Public Health Hundred, hundred and fifty thousand of the deaths, may be more could have been prevented. We just didn’t take it seriously, we didn’t do it right. https://www.youtube.com/watch?v=PxGU1dwg9b8 Moderna / NIH, 20m vaccines by the end of the year Seeking emergency authorisation for high-risk groups if it proves 70% effective Operation Warp Speed, nearly $1 billion Advanced orders, $1.5 billion Messenger RNA should be easier to mass produce than traditional vaccines 500m-1bn doses of the vaccine in 2021 Myanmar Cases, + 424 = 4,467 Biggest daily rise so far After weeks without confirmed domestic transmission Probably mostly in Yangon Deaths, 70 Iran In the grip of a third wave Cases, + 3,049 Deaths, + 144 Covid-19: Do many people have pre-existing immunity? https://www.bmj.com/content/370/bmj.m3563.full Studies that have documented SARS-CoV-2 reactive T cells 20% to 50% of people with no known exposure to the virus US, Netherlands, Germany, Singapore, UK, Sweden Alessandro Sette, (immunologist, La Jolla Institute for Immunology in California) At this point there are a number of studies that are seeing this reactivity in different continents, different labs. As a scientist you know that is a hallmark of something that has a very strong footing Common cold viruses, animal coronaviruses Possible overall reduced population susceptibility New York, London, and Stockholm Have not reverted to the old curve with lockdown restrictions Ongoing distancing measures Memory T cells Sweden, Family members of patients with confirmed covid-19 T cell responses found in those who were seronegative or asymptomatic While around 60% of family members produced antibodies 90% had T cell responses T cells were found in SARS patients 17 years after infection Swine flu, H1N1 Pre-existing reactive T cells had clinically milder disease Required prospective studies Mapping pre-existing reactivity to clinical outcomes Not being done in the placebo arm of the vaccine studies

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