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Oxford AZ vaccine https://uk.reuters.com/article/uk-health-coronavirus-india-vaccine/astrazeneca-vaccine-set-to-become-first-to-get-approval-in-india-sources-idUKKBN29628Y India approves Oxford vaccine India’s Central Drugs Standard Control Organization (CDSCO) Rollout to start Wednesday UK Argentina India What about Europe and the US? Europe, 400 million does US, 300 million doses On different topic https://news.sky.com/story/covid-19-vaccines-how-do-the-moderna-and-pfizer-coronavirus-jab-candidates-compare-12134062 https://www.businessinsider.com/cost-pfizer-astrazeneca-moderna-vaccine-eu-revealed-belgian-mp-2020-12?r=US&IR=T Oxford AstraZeneca $2.18 per dose Pfizer, $20 Moderna, $22.06 to $38 per dose Where is rollout going well Israel, 644,000 or 7% so far Bahrain UK US Canada Europe Oxford/AstraZeneca vaccine Phase 2 trials 56-day gap Phase 3 trials https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(20)32623-4/fulltext Good immunity with 6-week gap https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(20)32661-1/fulltext Efficacy after one dose, 64% Efficacy after 2 doses, 70 – 80% Cases, 21 days after first SD, 64% Vaccine group, 51 Control group, 141 Efficacy 64% Severe cases 21 days after the first dose of Oxford / AZ Vaccine group, 0 Control group, 10 hospitalised (2 severe, 1 death) Covid-19: Pfizer BioNTech vaccine efficacy was 52% after first dose and 95% after second dose https://www.nejm.org/doi/full/10.1056/NEJMoa2034577?query=RP https://www.bmj.com/content/371/bmj.m4826 Twelve days after the first dose Vaccine group, 39 cases Placebo group, 82 cases 52% efficacy Severe cases after one dose Vaccine group, 1 Placebo group, 9 New UK vaccine protocol Change to one dose, second within 3 months Statement from the UK Chief Medical Officers on the prioritisation of first doses of COVID-19 vaccines https://www.gov.uk/government/news/statement-from-the-uk-chief-medical-officers-on-the-prioritisation-of-first-doses-of-covid-19-vaccines Medicines and Healthcare products Regulatory Agency (MHRA) Oxford, 2 doses 4 to 12 weeks apart Pfizer, 2 doses 3 to 12 weeks apart The Joint Committee on Vaccination and Immunisation (JCVI) will protect the greatest number of at risk people overall in the shortest possible time and will have the greatest impact on reducing mortality, severe disease and hospitalisations and in protecting the NHS and equivalent health services. second doses of both vaccines will be administered towards the end of the recommended vaccine dosing schedule of 12 weeks The Green Book https://www.gov.uk/government/publications/covid-19-the-green-book-chapter-14a https://assets.publishing.service.gov.uk/government/uploads/system/uploads/attachment_data/file/948757/Greenbook_chapter_14a_v4.pdf If an interval longer than the recommended interval is left between doses, the second dose should still be given (preferably using the same vaccine as was given for the first dose). The course does not need to be restarted. There is no evidence on the interchangeability of the COVID-19 vaccines although studies are underway. Therefore, every effort should be made to determine which vaccine the individual received and to complete with the same vaccine. There is no evidence of any safety concerns from vaccinating individuals with a past history of COVID-19 infection, or with detectable COVID-19 antibody.

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