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Covid-19: New coronavirus variant is identified in UK https://www.bmj.com https://www.bmj.com/content/371/bmj.m4857 Driving infections in the south east What do we know? VUI-202012/01 Variant Under Investigation Defined by a set of 17 mutations Most significant is an N501Y mutation Spike protein More infectious How was the variant detected? Genomics UK Public health agencies, Wellcome Sanger Institute, 12 academic institutions Random genetic sequencing of positive samples around the UK Set up in April 2020, sequenced 140,000 virus genomes Uses the data to track outbreaks, identify variant viruses, publish old weekly report https://www.cogconsortium.uk/data/ How common is it? As of 13 December 1,108, 60 different local authorities Sunday, 20th 60% of new cases in London South east of England, Scotland Seeded every part of Wales Netherlands, Italy, Austria, Belgium flight ban, Eurostar to Belgium France and Germany expected soon First spotted in late September Now 20% of viruses sequenced in Norfolk Essex 10% Suffolk 3% No data to suggest it’s imported Does this variant spread more quickly? Initially it was a correlation Up to 70% more infectious Raising R value by 0.4 Is the new variant more dangerous? Porton Down Will the vaccine still work? May have an effect on neutralising antibodies

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