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Chinese and Western vaccines compared https://www.bbc.co.uk/news/world-asia-china-63855508 Big changes, all of a sudden Live with the virus Vice-premier, Sun Chunlan China entering a new situation Virus ability to cause disease weakening Lifting most severe Covid policies End of quarantine camps People can isolate at home No more family separations Close contacts not taken to camps Strict ban on blocking fire exits No need to show tests for venues Less rules on internal travel Lateral flow tests to replace PCR tests in most areas Lockdowns continue in smaller more targeted areas Foreign travel soon Cases, 30,000 + Now Everyone will be exposed Will the medical system will be overwhelmed? National Health Commission All localities, focus on improving the vaccination rate of people aged 60-79, accelerating the vaccination rate of people aged 80 and above, and making special arrangements Prof Ivan Hung, Hong Kong University The main way for China to exit Covid with the least damage is via vaccination and three doses of vaccination is a must Hopefully before Chinese New Year (January 22) Rabbit Sinopharm Strategic Advisory Group of Experts on Immunization (SAGE) https://www.who.int/news-room/feature-stories/detail/the-sinopharm-covid-19-vaccine-what-you-need-to-know The vaccine is safe and effective for all individuals aged 18 and above. Individuals may choose to delay vaccination for 3 months following the infection. An inactivated vaccine with adjuvant (that is routinely used in many other vaccines) with a documented good safety profile, including in pregnant women. Symptomatic SARS-CoV-2 infection and efficacy against hospitalization 79% Does it prevent infection and transmission? No substantive data Does it work against new variants of SARS- CoV-2 virus? SAGE currently recommends using this vaccine Not yet been evaluated in the context of circulation of widespread variants of concern. How does this vaccine compare to other vaccines already in use? We cannot compare the vaccines head-to-head, (different approaches taken in designing the respective studies) but overall, all of the vaccines that have achieved WHO Emergency Use Listing, are highly effective in preventing severe disease and hospitalization due to COVID-19. Comparison with Western vaccines Pfizer original paper https://www.nejm.org/doi/full/10.1056/NEJMoa2034577 https://www.nejm.org/doi/suppl/10.1056/NEJMoa2034577/suppl_file/nejmoa2034577_appendix.pdf BNT162b2 was 95% effective in preventing Covid-19 Later analysis from Efficacy and effectiveness of covid-19 vaccine - absolute vs. relative risk reduction https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9115787/ AAR, Pfizer, during the trial period, 0.84% AAR https://patient.info/news-and-features/calculating-absolute-risk-and-relative-risk Absolute risk of a disease is your risk of developing the disease over a time period. Five to six-months update, AAR BNT162b2 3.7% mRNA1273 (Moderna-NIH) 4.9%

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