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UK, Third injection https://www.telegraph.co.uk/news/2021/03/13/pensioners-may-get-vaccine-booster-august-avoid-winter-wave/ Pensioners, possible booster in August / September Waiting until winter could be too late Prof Anthony Harnden, Joint Committee on Vaccination and Immunisation Top up would be needed, protect against a new variant or as a safety net (as the duration of protection is unknown) Possible third wave affecting the vulnerable elderly next winter Annual Covid-19 vaccinations could be necessary in the years to come (Or not, if immunity lasts for a long time) AZ 14th March, vaccine is safe https://www.astrazeneca.com/media-centre/press-releases/2021/update-on-the-safety-of-covid-19-vaccine-astrazeneca.html 17 million people vaccinated in the European Union (EU) and UK with COVID-19 Vaccine AstraZeneca No increased incidence in any defined age group, gender, batch or in any particular country. 8 March data 15 events of DVT and 22 events of pulmonary embolism Much lower than would be expected to occur naturally In clinical trials, number of thrombotic events was small, lower in the vaccinated group No evidence of increased bleeding in over 60,000 participants enrolled. there are also no confirmed issues related to any batch of our vaccine used across Europe, or the rest of the world Quality testing, 60 quality tests are conducted by AstraZeneca 20 independent testing laboratories Epidemiology of venous thromboembolism https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4624298/ Incidence rate Men, 130 per 100,000 per year Women, 110 per 100,000 per year That’s 10 per month per 100,000 That’s 120 per million per month Therefore for 3 million of the population 360 thromboembolic events expected per month Early data, vaccination and long covid Vaccine may alleviate symptoms in long Covid Patient groups and scientists About 10% symptomatic for 12 weeks, some longer 20 to 50% reduced symptoms, fatigue, headaches, brain fog Effects may be temporary Dr David Strain, University of Exeter Runs long Covid clinics, member of the NHS long covid taskforce We are getting people reporting improvements, and it’s quite widespread, about half of the people we are asking. There is a major reporting bias, though - the people who notice something remarkable are the ones shouting about it.” This provides a bit of hope for people who have been struggling with this for 12 months or more, just to feel better for a bit. But also as researchers it tells us a lot of information: does this give us clues about how we should be treating it? We need to look very carefully Lou Barnes, coordinates 4,000-strong Post Covid Syndrome support group Estimates 20% Improvements lasting for around three weeks Others reported feeling worse for a short time Professor Danny Altmann, immunologist, Imperial College, London It’s very interesting because we still have no clue about the mechanisms in long Covid and what to do for patients, and also because many sufferers are very anxious about their immune status. This has led to some paradoxical vaccine hesitancy Professor Eleanor Riley, immunologist, University of Edinburgh One of the hypotheses about chronic fatigue syndrome is that it is a failure of the immune system to reset after a viral infection. And if that’s the case, then giving the immune system a jolt, for example by vaccination, may help to reset. But that is purely speculation It’s possible it may turn out to be random Seems to be two forms of long covid After severe and milder disease CoViD tongue https://covid.joinzoe.com/post/covid-tongue Previously reported mouth and tongue changes Dry mouth, loss of taste (dysgeusia) and fungal infection (oral thrush). Changes in tongue sensation, muscle pain while chewing, swelling in the mouth and ulcers on the tongue or inner surface of the mouth and lips https://onlinelibrary.wiley.com/doi/10.1111/dth.14717 Reporters ask to identify new features Loss of smell, skin rashes, delirium Tongue doesn’t look normal, white and patchy What causes COVID tongue? Could be direct viral effect or an immune response Increased susceptible to fungal infections in the mouth However, anti-fungals don’t seem to work How common is COVID tongue? Up to a quarter of hospitalised patients had tongue or mouth changes https://onlinelibrary.wiley.com/doi/10.1111/bjd.19564 Less common mild disease Don’t knows If it can be an isolated feature When in the condition it arises Now a specific question

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