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https://www.healthline.com/nutrition/how-much-vitamin-d-to-take#How-Common-Is-Vitamin-D-Deficiency About 42% of the US population is vitamin D deficient 82% in black people 70% in Hispanics Association of Vitamin D Status and Other Clinical Characteristics With COVID-19 Test Results, (JAMA Open, 3rd September, Chicago) https://jamanetwork.com/journals/jamanetworkopen/articlepdf/2770157/meltzer_2020_oi_200688_1598473478.89934.pdf Cohort study of 489 Patients who had a vitamin D level measured in the year before COVID-19 testing Relative risk of testing positive for COVID-19 was 1.77 times First clinical trial on vitamin D and COVID Therapy versus best Available Therapy on Intensive Care Unit Admission and Mortality Among Patients Hospitalized for COVID-19: A Pilot Randomized Clinical study" (Spain, Journal of steroid biochemistry and molecular biology) https://www.sciencedirect.com/science/article/pii/S0960076020302764 Objective Vitamin D decreases Acute Respiratory Distress Syndrome Effect of calcifediol treatment Calcifediol can rapidly increase serum 25OHD concentration 25-hydroxyvitamin D Intensive Care Unit Admission and Mortality Spanish patients hospitalized for COVID-19. Design Parallel pilot, randomized, double-masked clinical trial Setting Reina Sofia University Hospital, Córdoba, Spain Participants 76 consecutive patients hospitalized with COVID-19 infection Clinical picture of acute respiratory infection Confirmed by a radiographic pattern of viral pneumonia Positive SARS-CoV-2 PCR Procedures All hospitalized patients received as best available therapy Hydroxychloroquine and azithromycin Allocated at a 2 calcifediol:1 Oral calcifediol (0.532 mg), or not Oral calcifediol (0.266 mg) on day 3 and 7 Then weekly until discharge End points, ICU admission and deaths. Results 50 patients treated with calcifediol One required admission to the ICU (2%), Of 26 untreated patients, 13 required admission (50%) p  less than 0.001 Of the patients treated with calcifediol, none died, and all were discharged, without complications Of the patients not treated, 2 died Conclusion Calcifediol seems to be able to reduce severity of the disease Larger trials with groups properly matched will be required to show a definitive answer Rationale, activation of the vitamin D receptor (VDR) signalling pathway Reduced ARDS Cytokine/chemokine storm Regulating the renin angiotensin system Modulating neutrophil activity Maintaining the integrity of the pulmonary epithelial barrier Stimulating epithelial repair Tapering down the increased coagulability Ventilate Don't abdicate Dilute that virus So you stay great Ventilate Don't complicate, Complain or whine You'll acclimate Contemplate When you congregate Does the air here circulate Instigate, Nominate Educate, Motivate I hope this message will resonate That when we populate Instead of isolate Ventilate Don't abdicate Dilute that virus So you stay great

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