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Individuals with autism suffer from multiple co-morbid conditions. Immune mediated inflammation that affects not only the brain but also other organs has been implicated in many of the observed clinical features of autism. However, inflammation in autism appears not associated with specific environmental factors, but appears to be driven by innate immune memory (IIM) responses that are generated by metabolic and epigenetic changes triggered by an initial stimulus. Dr Jyonouchi’s research attempts to determine the underlying mechanisms of immune mediated inflammation and their effects on the development and progress of Autism Spectrum Disorder ASD. The central hypothesis is that mal-adapted IIM results in dysregulated innate immune responses to multiple, unrelated environmental factors, leading to puzzling arrays of clinical features and multiple co-morbid conditions in ASD. Dr Jyonouchi is a board certified allergist/immunologist practicing at Saint Peter's University Hospital, and a Clinical Professor of Pediatrics at Rutgers Robert Wood Johnson Medical School. She is the recipient of a number of honors and awards, and has served on NIH grant review committees and Editorial Boards. She has had continuous grant support since 1989 and is the author of over 100 published peer-reviewed articles and chapters. Her research interests include: neuro-immune interactions and epigenetic regulation in children with ASD, innate immune abnormalities in patients with mucosal inflammation of the airway (asthma) and the GI tract, and non-IgE mediated food allergy. #allergy #immunology #immunesystem #inflammation This talk was part of Synchrony 2020 Online Symposium - 'From Bench to Biopharma', organised by the The BRAIN Foundation in partnership with UC Davis MIND Institute and CalTech. For more Synchrony 2020 presentations: https://www.youtube.com/playlist?list=PLDtO9h17tcWcRGZHOgtNG9YMJ7BJkO6VR 🧠 🧠 🧠 🧠 🧠 🧠 🧠 🧠 🧠 🧠 🧠 🧠 🧠 🧠 Synchrony https://synchronysymposium.com/ is the first and only international symposium on translational research in #autism, that brings together academia, #biotech, pharmaceutical companies and #venture partners from around the world with the mission to improve health and quality of life of people with #autismspectrumdisorder. 🧠 🧠 🧠 🧠 🧠 🧠 🧠 🧠 🧠 🧠 🧠 🧠 🧠 🧠 The BRAIN Foundation https://brainfoundation.org/ is a 501c(3) non-profit. The founders of BRAIN envision a world where every child and adult on the autism spectrum is healthy, participates fully in education and employment, and has a better quality of life. It aims to catalyze research that results in evidence-based interventions for the disabilities associated with autism, and also results in better medical standard of care. To accomplish this, it funds impactful research through #philanthropy and our network of partners in the venture, corporate, and grassroots community.

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