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Why does dehydration give you a headache, when your brain has no pain receptors at all? Surgeons can operate on a brain while the patient is awake and talking, yet skip a few glasses of water and your whole head pounds. So why does dehydration cause headaches, and where is that pain really coming from? The answer lies in the space around your brain. It floats in a cushion of fluid, wrapped in the meninges and tied to the skull by blood vessels and fine strands, all lined with pain sensors. When you run low on water, your blood grows saltier and water slips out of your cells. One leading idea is that the brain shrinks when dehydrated, just slightly, and brain scans of volunteers have shown brain volume dropping with dehydration and returning after a drink. A smaller brain tugs on everything holding it in place, and the signal races along the trigeminal nerve. Can dehydration cause headaches that feel worse when you bend over or walk? It can, and we look at why you get a headache when dehydrated, how a water deprivation headache eased within hours of drinking in one small study, why a hangover headache is partly about vasopressin and alcohol, and why the classic dehydration headache is your body's way of asking for water. This video is for curiosity and education only, not medical advice. #dehydrationheadache #headache

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