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Vitamin D UK biobank https://www.ukbiobank.ac.uk Habitual use of vitamin D supplements and risk of coronavirus disease 2019 (COVID-19) infection: a prospective study in UK Biobank (29th January, 2021) https://academic.oup.com/ajcn/advance-article/doi/10.1093/ajcn/nqaa381/6123965 The American Journal of Clinical Nutrition Background Vitamin D supplementation, lower risk of acute respiratory tract infection Emerging evidence, vitamin D insufficiency is related to a higher risk of coronavirus infection and disease Objectives To investigate the prospective association between habitual use of vitamin D supplements and risk of COVID- 19 infection Associations according to levels of circulating and genetically predicted vitamin D Methods N = 8,297 adults Records of COVID-19 test results from UK Biobank 16 March 2020 to 29 June 2020 Results Of the 8,297 adults, 1,374 (16.6%) tested positive Vit D users, n = 363 Non-vit D users, n = 7,934 Unadjusted model OR 0.78 (p = 0.105) Adjustment for covariates Age, sex, race, origin (outpatient or inpatient), blood-type, years of education, TDI, smoking, moderate drinking, physical activity, healthy diet score, use of any other supplements Inverse association emerged Between habitual use of vitamin D supplements and risk of COVID-19 infection OR, 0.66, (P = 0.038) Habitual use of vitamin D supplements was significantly associated with a 34% lower risk of COVID-19 infection No association with baseline blood vitamin D levels and risk of COVID-19 infection Associations between the risk of COVID-19 infection and habitual use of other individual supplements Vitamin A, vitamin B, vitamin C, vitamin E, folic acid, a multivitamin, Calcium, zinc, iron, selenium, glucosamine, fish Oil Vitamin D Deficiency and Outcome of COVID-19 Patients Medical University Hospital Heidelberg, (September 2020) https://www.mdpi.com/2072-6643/12/9/2757 Identification of modifiable prognostic factors may help to improve outcomes N = 185, diagnosed and treated in Heidelberg Median Vitamin D level was 16.6 ng/ml Associations of vitamin D status with disease severity and survival Vitamin D status assessed at first presentation Deficient 25-hydroxyvitamin D (Calcifediol) level less than 12 ng/mL ( less than 30 nM) N = 41 (22%) Median IL-6 levels at hospitalization were significantly higher 70.5 versus 29.7 pg/mL Insufficiency Less than 20 ng/mL (less than 50 nM) N = 118 (64%) Higher levels N = 26 Median Vitamin D level was significantly lower in the inpatient versus the outpatient subgroup Results Median observation period of 66 days 93 (50%) patients required hospitalization 28 patients required ventilation Including 16 deaths Adjusting for age, sex, comorbidities Deficiency was associated with higher risk of ventilation and death Mechanical ventilation HR 6.12 p less than 0.001 Death HR 14.73 p less than 0.001 Other hazard ratios Male, 1.69 2.5 Over 60, 3.2 7.7 Comorbidity, 2.7 5.3 Need for interventional studies Cholecalciferol Calcifediol Active form of vitamin D3, 1, 25-dihydroxyvitamin D3 (1,25D3), calcitriol, is pluripotent hormone and important modulator of both innate and adaptive immunity

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