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Coronavirus antibody prevalence falling in England, REACT study shows (Imperial college and Ipsos MORI, 27th October) https://www.imperial.ac.uk/news/207333/coronavirus-antibody-prevalence-falling-england-react/ https://www.imperial.ac.uk/media/imperial-college/institute-of-global-health-innovation/MEDRXIV-2020-219725v1-Elliott.pdf N = 365,000 antibody tests Positive tests = 17,576 30% of whom did not report any COVID-19 symptoms 20 June and 28 September Three rounds Decline between rounds 1 and 3 in all age groups Decline was largest in people who didn’t report a history of COVID-19 Asymptomatics Dropped by 64.0% between rounds one and three Antigen diagnosed group Decrease of 22.3% between rounds one and three Overall decline Percentage testing positive, 6.0% to 4.8% and then 4.4% (a 26.5% reduction across the study period) All areas of the country and age groups, but higher in London (9% at round 3) But not in health workers Decline was largest in people 75 and older Professor Paul Elliott Our study shows that over time there is a reduction in the proportion of people testing positive for antibodies. Testing positive for antibodies does not mean you are immune to COVID-19. It remains unclear what level of immunity antibodies provide, or for how long this immunity lasts. If someone tests positive for antibodies: they still need to follow national guidelines including … social distancing measures getting a swab test if they have symptoms and wearing face coverings where required Implications for immunity SARS, 2002 – 2003 8,000 infections 774 deaths https://www.who.int/ith/diseases/sars/en/ Guangdong, southern China Toronto Hong Kong Taipei, Singapore Hanoi SARS-CoV-2-specific T cell immunity in cases of COVID-19 and SARS, and uninfected controls (Nature 15th July) https://www.nature.com/articles/s41586-020-2550-z?flip=true Memory T cells induced by previous pathogens can greatly influence future infections Individuals convalescing from COVID-19 n = 36 All had N protein recognising T cells Patients who recovered from SARS (One, 2003) n = 23 Possess long-lasting memory T cells, reactive to the N protein of SARS-CoV These have lasted for 17 years These T cells displayed robust cross-reactivity to the N protein of SARS-CoV-2 We also detected SARS-CoV-2-specific T cells in individuals with no history of SARS or COVID-19 (n = 37) In some people with no previous SARS one or two, or exposure to contacts SARS-CoV-2-specific T cells in uninfected donors exhibited a different pattern of immunodominance Targeting different proteins on the N protein These proteins are highly conserved in animal betacoronaviruses But have low homology to ‘common cold’ human-associated coronaviruses So Infection with betacoronaviruses induces multi-specific and long-lasting T cell immunity against the structural N protein Vaccine, early months of next year, Matt Hancock https://www.telegraph.co.uk/global-health/science-and-disease/coronavirus-news-uk-latest-cases-deaths-airport-tests-schools/ Oxford, AstraZeneca, AZD1222 30 million doses under UK manufacture Roll-out first half of 2021 Some people vaccinated 2020 Immune response similar across all age groups Strong immune response in elderly Encouraging to see immunogenicity responses were similar between older and younger adults (AZ) Lower levels of side-effects in older adults Elderly usually have a reduced immune response (e.g. influenza vaccine) Antibodies and T-cells Brazil, India, South Africa, UK, US Medicines and Healthcare products Regulatory Agency Food and Drug Administration Art work from Charles https://www.instagram.com/skoutone/ If you would like to donate to John's educational projects, please use the following link, thank you, https://www.paypal.com/cgi-bin/webscr?cmd=_s-xclick&hosted_button_id=78GGHGLK5ZXAE

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