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Professor of Oncology, Angus Dalgleish gives vital information on a repurposed drug he uses for his cancer patients, given at a very low dose. This is Low Dose Naltrexone. Check out the LDN trust website for much more, https://ldnresearchtrust.org Naltrexone at low doses (LDN) and its relevance to cancer therapy https://openaccess.sgul.ac.uk/id/eprint/114135/ Naltrexone was designed to inhibit opioid receptors without activating them and hence used to block the stimulatory effects of morphine and heroin. It was noted that in certain patients being treated with naltrexone for an opioid addiction many reported significant secondary benefit when being weaned off naltrexone. This group of patients had chronic inflammatory and autoimmune conditions and reported improvements whilst using the lower dosages of naltrexone. There have also been recent anecdotal reports of cancer resolution following the use of low doses of naltrexone (LDN). However, the mechanism of action is unclear. Areas covered We review three mechanisms through which LDN can influence cancer progression; namely, (a) antagonism of receptors to which LDN binds, which include toll-like receptors 7–9 that lead to IL-6 suppression b) modulation of immune function in patients; and c) direct inhibition of signaling pathways involved in cancer cell control, including the priming of pro-apoptotic pathways. Expert opinion Considering the increase in the number of anecdotal reports of activity, there will likely be a bigger drive toward using LDN in the oncological setting. These reports support clinical trials of LDN in cancer, especially when given in combination with certain chemotherapy. https://ldnresearchtrust.org/angus-dalgleish-md-role-ldn-management-cancer-2018-conference-ldn-low-dose-naltrexone Major clinical evidence on the use of low-dose naltrexone in the treatment of cancer: a systematic review https://www.researchgate.net/publication/384236060_Major_clinical_evidence_on_the_use_of_low-dose_naltrexone_in_the_treatment_of_cancer_a_systematic_review https://www.tandfonline.com/doi/full/10.1080/14737140.2022.2037426#abstract

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