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Granola is the AI notepad for professionals in back-to-back meetings. Get your first month of Granola free: https://www.granola.ai?via=inside-startups Supercool Earth is a pre-seed Silicon Valley startup engineering a protein that makes clouds produce rain and snow at warmer temperatures than existing cloud seeding chemicals. In this episode, I go behind the scenes with Dacia Leon and Michelle Grau, the founders of Supercool Earth, inside IndieBio’s lab in San Francisco. Both are fungal biologists, and Dacia spent her career in industrial biology before starting the company. They are backed by SOSV through the IndieBio accelerator and by Superorganism, the first venture fund dedicated to biodiversity. Most precipitation starts as ice. The water is already sitting in the cloud, and it needs something to freeze around before it can fall. Cloud seeding works by supplying that something, and since the technique was invented in 1946 the industry has mostly used silver iodide, which only triggers freezing in a narrow band of cold enough clouds. Supercool Earth’s ice-nucleating protein is made naturally by soil microbes, already drifts through dust and into clouds, and has been engineered into a fungus so it can be produced by fermentation. It triggers freezing a few degrees warmer than silver iodide, and the founders say that widens the range of usable clouds by [25% to 55%]. It works on storms that already carry the conditions for precipitation, rather than generating weather from a clear sky. Weather modification is now a venture category. Rainmaker raised a $25M Series A led by Lowercarbon Capital to attack the same problem with drones. Supercool Earth is attacking it from a lab bench with biology. The protein supports two markets. The near-term one is snow. Ski resorts run snow guns around the clock through winter, but those guns only work below a certain temperature, so resorts lose days at both ends of the season and lose runs entirely in a warm year. A nucleating additive lets them make snow at higher temperatures, which means opening earlier, closing later, and covering more terrain. Resorts already buy an additive to do this, and the founders’ pitch is that theirs is more stable and does not smell of sulphur. It is a market that pays now, and the revenue is there to fund the slower science. The larger bet is agriculture. Roughly 80% of the world’s cropland is rain-fed, which makes it entirely dependent on rainfall patterns that are getting harder to predict. Inside this episode: - Inside IndieBio’s shared San Francisco lab, and what a pre-seed biotech actually runs on - How a fungus is engineered to produce the protein, scaled from 50ml flasks to 1,000 litres - The freezing assay: thermal cameras, sub-zero plates, and testing which strain performs - Why biologists and atmospheric scientists have to build a shared language to run this company - How the ski resort product was designed to pay for the agricultural one - What it takes to displace a chemical that costs almost nothing - Where cloud seeding is regulated, and what it takes to put anything into a cloud Cloud seeding is 80 years old and still contested. Silver iodide is cheap, the industry is small, and researchers have spent decades struggling to prove that rain they made would not have fallen anyway. Supercool Earth is betting that a few degrees of extra range is enough to change the economics, with two founders and a fraction of the capital of the companies flying drones at the same problem. So the question I wanted to answer is whether a protein is enough to win a category this hard. Check out Supercool Earth: https://link.willphillips.co/Supercool-Earth Find Startup Jobs: https://link.willphillips.co/startup-jobs Join my founder newsletter: https://link.willphillips.co/newsletter   Let’s connect: X: https://link.willphillips.co/Twitter Instagram: https://link.willphillips.co/Instagram LinkedIn: https://link.willphillips.co/LinkedIn Episode Chapters: 00:00 Introduction 02:37 Inside Supercool Earth’s lab 03:21 Interview with founder Dacia Leon (Co-founder) 03:57 Production meeting 04:50 Granola, the AI meeting assistant 05:07 Interview with Michelle Grau (Co-founder) 06:28 Supercool Earths focus 08:15 Product review meeting 10:06 Interview with Wolfgang Langhans (Atmospheric Scientist and Software Engineer) 11:58 Visit from Rohit Gupta (VC, Future Communities Capital) 13:30 Dacia’s advice to founders

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