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E mail from CDC to CNN, Breakthrough infections https://www.medscape.com/viewarticle/949381?src=wnl_edit_tpal&uac=127834AR&impID=3316056&faf=1 https://edition.cnn.com/2021/04/14/health/breakthrough-infections-covid-vaccines-cdc/index.html Vaccinated people who become infected = 5,800 About 1 in 13,275 At least 14 days after their final dose Asymptomatic, 29% Required hospitalization = 396 (1 in 194,444) Deaths = 74 (1 in 1,040,540) CDC currently investigating factors May be more cases to report due to reporting lag From 77 million fully vaccinated (Fully vaccinated as of today = 80.6 million) From trials Pfizer/BioNTech, 95% effective in preventing symptomatic disease Moderna, 94% effective in preventing symptomatic illness Johnson & Johnson, 72% from US data Characteristics of breakthroughs so far 40% of the infections were in people 60 or more 65%, were female CDC is monitoring reported cases for clustering by patient demographics, geographic location, time since vaccination, vaccine type or lot number, and SARS-CoV-2 lineage CDC also continues to recommend people who have been fully vaccinated should keep taking precautions in public places, like wearing a mask, staying at least six feet apart from others, avoiding crowds and poorly ventilated spaces, and washing their hands often Dr. Carlos del Rio, Emory University School of Medicine Less transmission means fewer breakthrough cases There is currently a lot of transmission in many parts of the country Vaccines will help decrease that Get vaccinated as soon as you can and help control this pandemic National Institutes of Health Director Dr Francis Collins Allow more time for scientists to investigate links between the vaccine and blood clots and whether or not certain groups of people are more susceptible India, double mutation variant emerge Hey john thanks for the update. I am from Delhi, India and I have contracted the virus. Situation in India is very bad. Most of the hospitals are already exhausted and many people are dying without treatment. The India variant, B.1.617 E484Q and L452R First reported in India, late 2020 Aparna Mukherjee, Indian Council of Medical Research has not been stamped as a ‘variant of concern’ so as to say that it is more lethal or more infectious But https://www.healio.com/news/infectious-disease/resources/outbreak-tracker Very low prevalence in January April, 52% of samples sequenced Maharashtra state, 60% Has been detected in 10 other countries, US, UK (77 cases) Australia and New Zealand (L452 from US data, 20% more transmissible, reduces antibody efficacy by more 50%) William A. Haseltine, former professor, Harvard Medical School The B.1.617 variant has all the hallmarks of a very dangerous virus We must do all that is possible to identify its spread and to contain it Brazil https://www.washingtonpost.com/nation/2021/04/16/coronavirus-covid-live-updates-us/ Trying to get more drugs from Spain Rio de Janeiro, health-care workers forced to intubate patients without sedatives Mechanical restraints and neuromuscular blockers Doctors Without Borders More than 12 months into Brazil’s covid-19 emergency, there is still no effective, centralized and coordinated public health response to the outbreak The lack of political will to adequately respond to the pandemic is killing Brazilians in their thousands

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