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Omicron BA.2 Variant, is this going to be another wave? If you would like John’s text books, (it is free to download the PDFs) Link to free download of my 2 textbooks http://159.69.48.3/ Physiology book in hard copy https://www.ebay.co.uk/itm/154770452796?mkevt=1&mkcid=16&mkrid=710-127635-2958-0 Pathophysiology book in hard copy https://www.ebay.co.uk/itm/154770451780?mkevt=1&mkcid=16&mkrid=710-127635-2958-0 Original omicron, B.1.1.529 https://www.who.int/en/activities/tracking-SARS-CoV-2-variants/ PANGO Lineage is described as a cluster of sequences that are associated with an epidemiological event, Phylogenetic Assignment of Named Global Outbreak Lineages (PANGOLIN) Omicron includes Pango lineage B.1.1.529 and descendent Pango lineages BA.1, BA.1.1, BA.2 and BA.3. BA.2 is a descendent lineage ‘Omicron plus’ Identified, Philippines, then to India https://www.medpagetoday.com/special-reports/exclusives/96833 https://www.independent.co.uk/news/science/covid-omicron-variant-ba2-latest-b2000044.html Omicron sublineage BA.2 10,000 cases of BA.2, 40 countries Potentially increased transmissibility over omicron clade BA.1 U.K. Health Security Agency, VUI Cases doubling every 4 days 120% growth advantage over original Omicron clade (Delta to Omicron, 500% growth advantage) Similar growth, Denmark, Norway, Sweden, India Does not have the same s-gene target failure on PCR as omicron BA.1 BA.2 is S gene positive BA.1, 60 mutations BA.2, 80 mutations https://www.telegraph.co.uk/global-health/science-and-disease/ba2-new-omicron-sub-variant-could-prolong-uk-epidemic-warn-experts/ Meaghan Kall, UKHSA https://twitter.com/kallmemeg/status/1485198018953555969 no evidence at all yet that it can evade Omicron (BA.1) immunity or be different to Omicron in any meaningful way Variants will continue to emerge, but not all variants will be a problem Only having a transmissibility advantage at this stage of the game (with population immunity so high) isn't a total showstopper Little difference in vaccine effectiveness between BA.1 and BA.2 Disease severity, comparable to BA.1 Unlikely to be another BA.2 omicron wave Denmark BA.2 now accounts for 65% of new cases Early data, not been associated with an increase in hospitalisations Norway Increase in BA.2 in Oslo Concurred that BA.2 is likely more contagious than BA.1. Question Can those infected with the BA.1 get re-infected with BA.2. French Health Minister, Olivier Veran https://www.aljazeera.com/news/2022/1/22/omicron-sub-variant-throws-up-new-virus-questions What we know for now is that BA.2 more or less corresponds to the characteristics that we know of Omicron Robert Garry, virologist Tulane University School of Medicine https://www.washingtonpost.com/health/2022/01/24/covid-omicron-ba2/ Variants have come, variants have gone I don’t think there’s any reason to think this one is a whole lot worse than the current version of omicron James Musser, Center for Molecular and Translational Human Infectious Diseases Research, Houston Methodist The good news is we have only three We certainly do not see the 5% and more reported in the U.K Certainly not the 40% in Denmark We know that omicron … can clearly evade preexisting immunity, from both vaccines and exposure to other variants of the virus, What we don’t know yet is whether son-of-omicron does that better or worse than omicron. So that’s an open question. Anders Fomsgaard, virologist, State Serum Institute Denmark BA. 2 has become the dominant form of the virus in his nation of nearly 6 million people, where it now accounts for about 65% of new cases as BA. 1 is on the decline we are not so concerned, since we so far do not see major differences in age distribution, vaccination status, breakthrough infections and risk of hospitalization. Also, despite the high infection rate of BA. 2, the numbers in ICUs are decreasing Francois Balloux, professor of computational biology, University College, London https://www.telegraph.co.uk/global-health/science-and-disease/ba2-new-omicron-sub-variant-could-prolong-uk-epidemic-warn-experts/ BA.2 about 20 mutations apart from the original BA.1 the two omicron sub lineages are sister clades that split from other several months ago, and are not derived from each other People infected with one of the lineages would have “robust immunity” against the other one At this stage, BA.1 and BA.2 can be considered as two epidemiologically largely equivalent sub-lineages of omicron

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