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COVID-19 Mortality Risk Correlates Inversely with Vitamin D3 Status, a Mortality Rate Close to Zero Could Theoretically Be Achieved at 50 ng/mL 25(OH)D3: (125 nmol/L) Results of a Systematic Review and Meta-Analysis https://www.mdpi.com/2072-6643/13/10/3596 Blood calcifediol (25(OH)D3) levels correlate strongly with SARS-CoV-2 infection severity Cause or effect? Strength of our immune system, More or less neglected by the responsible authorities Nutrition, physical fitness, recreation, sleep Widespread vitamin D deficiency Data collected March 2021 Methods Systematic literature search Retrospective cohort studies (1) Clinical studies (7) on COVID-19 mortality rates versus D3 blood levels Reported D3 blood levels pre-infection or on the day of hospital admission Mortality rates, corrected for age, sex, and diabetes Results Negative Pearson correlation of D3 levels and mortality risk r = −0.4154, p = 0.0770 r = −0.4886, p = 0.0646 Combined data Median D3 levels were 23.2 ng/mL (58 nmol/L) Pearson correlation = −0.3989, p = 0.0194 Regression suggested a theoretical point of zero mortality at approximately 50 ng/mL (125 nmol/L) D3 Conclusions The datasets provide strong evidence that low D3 is a predictor rather than just a side effect of the infection. Despite ongoing vaccinations, we recommend raising serum 25(OH)D levels to above 50 ng/mL

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