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A Randomized Trial of Hydroxychloroquine as Postexposure Prophylaxis for Covid-19 (3rd June) BACKGROUND Whether hydroxychloroquine can prevent symptomatic infection after SARS-CoV-2 exposure is unknown. METHODS Randomized, double-blind, placebo-controlled trial United States and Canada Testing hydroxychloroquine as postexposure prophylaxis High risk, less than 6 ft for more than 10 minutes while wearing neither a face mask nor an eye shield Moderate risk, while wearing a face mask but no eye shield n = 821 asymptomatic participants (719 of 821) reported a high-risk exposure Randomly assigned, placebo or hydroxychloroquine groups within 4 days of exposure Primary outcome, incidence positive test of clinical diagnosis RESULTS Incidence of new illness Hydroxychloroquine group (49 of 414), 11.8% Placebo group (58 of 407), 14.3% P=0.35 Side effects in hydroxychloroquine group = 40.1% Side effects in control group = 16.8% No serious adverse reactions were reported. (Nausea, upset stomach, dizziness, headache) Hydroxychloroquine group Taking zinc 15% developed new disease Not taking zinc 10.8% developed new disease Placebo group Taking zinc 15.4% developed new disease Not taking zinc 14% developed new disease Relative risk with zinc use was 1.23 Hydroxychloroquine group Taking Vit C 14.3% developed new disease Not taking Vit C 10.6% developed new disease Placebo group Taking Vit C 20.8% developed new disease Not taking Vit C 11.2% developed new disease Relative risk with vitamin C use was 1.60 The Lancet (and NEJM) Hydroxychloroquine or chloroquine with or without a macrolide for treatment of COVID-19: a multinational registry analysis, (May 22nd) Serious scientific questions about the validity of data ‘Expression of Concern’ https://www.thelancet.com/journals/lanpub/article/PIIS0140-6736(20)31290-3/fulltext Issued a correction regarding location of some patients Conclusions were not changed. WHO resumed its trial of hydroxychloroquine Crisis of trust Medical journals WHO Governments Scientific / medical advisors
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