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Explore POV: Sickle Cell Under a Miscroscope with 109,290 views, 4,401 likes, and 96 comments. Experience the impact of this video content that has captured audience attention.

Sources- PMID 23103089 kindlefromthelab on TT Sickle cell trait occurs when inheriting one mutated hemoglobin gene alongside a normal one, causing some red blood cells to sickle under stress. When the malaria-causing *Plasmodium* parasite invades these cells, it lowers internal oxygen and pH, triggering the abnormal hemoglobin to form rigid chains. This forces infected cells to collapse early, signaling the immune system to destroy them before the parasite replicates. This sickling restricts parasite growth and stops infected cells from adhering to blood vessel walls. By lowering the parasite burden and preventing vessel blockages, sickle cell trait shields against severe, life-threatening malaria complications. This evolutionary benefit explains why the trait remains prevalent in historically malaria-endemic regions. #malaria #sicklecell #genetics

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