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Vary greatly on the two sides of the pond. US goes one way, the UK another. UK, awaiting rule change for 2 dosers https://www.bbc.co.uk/news/health-56929483 Indoor gatherings Wales, 3rd May England, Scotland 17th May NI, 24th May Prof Jonathan Van-Tam If two people who both had two doses of vaccine, and have both served at least 14 days after their second dose, then I would be highly confident scientifically that if they were reputable vaccines then indeed it would be incredibly safe for those two people to meet Paul Hunter, Professor of Medicine, University of East Anglia True just now with B117 The issue is variants with escape mutations that are less affected by the vaccine, and we haven't come to clear understanding of what those risks are UK, Indian or South African variants yet to make an impact https://covid.joinzoe.com/post/indian-or-south-african-variants-yet-to-make-an-impact 22nd April India https://www.aljazeera.com/news/2021/5/1/fire-in-hospitals-intensive-care-kills-18-in-indias-gujarat https://www.washingtonpost.com/nation/2021/04/29/coronavirus-covid-live-updates-us/ Cases, + 379,257 + 386,452 + 401,993 = 19,100,000 Deaths, + 3,645 + 3,523 = 211,853 Vaccinations All adults now eligible Was over 45s One dose, 10% Two doses 1.5% India / Australia Criminal offence for citizens to return home, from Monday India / US Restrictions from 4th May Most non-US citizens, India within the last 14 days will not be allowed into US India / France First case was detected in Lot-et Garonne, in southwestern France The patient is currently hospitalised in Bordeaux https://www.lexpress.fr/actualite/societe/sante/ce-que-l-on-sait-des-differents-cas-de-variants-indiens-detectes-en-france_2149875.html Two more cases in the south east – in the Marseille département of Bouches-du-Rhône. Two people returning from India without any link to one another 10-day quarantine for arrivals from India, Brazil, South Africa, Chile and Argentina https://www.thelocal.fr/20210430/three-cases-of-the-indian-variant-of-covid-detected-in-france/?utm_source=piano&utm_medium=email&utm_campaign=213&tpcc=newsletter_members&pnespid=1fBz_aVRDRWNUoF70GTcVJXtQlLxVSWUNbDvEHY Sequencing rate https://www.washingtonpost.com/nation/2021/04/29/coronavirus-covid-live-updates-us/#link-UVLBM3S2DFH65KGAD5772HMJ6Q Iceland, 78.8% Australia, 60.3% New Zealand, 48.5% Denmark, 20.2% Taiwan, 16% UK, 8.7% Norway, 5.6% Vietnam, 5.5% US, 1% India (102) 18,000,000 (10,626) 0.06% U.S. government, $100 million worth of supplies US State Department, U.S. citizens to leave India as soon as it is safe to do https://in.usembassy.gov/health-alert/ Spread from cities to small towns https://www.bbc.co.uk/news/world-asia-india-56913047 Spread now occurring, but underreported Corruption and black markets Medical debt already a big problem in India Remdesivir problem https://bnf.nice.org.uk/medicinal-forms/remdesivir.html Remdesivir for the Treatment of Covid-19 — Final Report (NEJM, 5th November 2020) https://www.nejm.org/doi/full/10.1056/nejmoa2007764 Double-blind, randomized, placebo-controlled trial of intravenous remdesivir Ten day course Hospitalized with Covid-19 with evidence of lower respiratory tract infection N = 1062 Remdesivir group, 541 Placebo, 521 Remdesivir group, n = 541 Median recovery time, 10 days Need for oxygen, 13 days Mortality by day 15 was 6.7% Mortality by day 29 was 11.4% Placebo controls, n = 521 Median recovery time 15 days Need for oxygen, 21 days Mortality by day 15 was 11.9% Mortality by day 29 was 15.2% (HR = 0.73) Serious adverse events Remdesivir group, 24.6% Placebo group, 31.6% Serious adverse events in placebo group, 31.6%

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