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Autopsy-based histopathological characterization of myocarditis after anti-SARS-CoV-2-vaccination https://link.springer.com/article/10.1007/s00392-022-02129-5#Sec3 Likelihood assessment of vaccine-induced (epi-)myocarditis Causality or correlation? Presence of myocarditis with temporal association to vaccination event AND Integration of histological phenotype, clinical presentation, and laboratory findings indicate no alternative differential diagnosis Abstract infographic Cases of myocarditis Have been diagnosed clinically, by laboratory tests, imaging (in the context of mRNA-based anti-SARS-CoV-2 vaccination) Autopsy-based description We describe, Cardiac autopsy findings and common characteristics of myocarditis, with vaccine-induced myocardial inflammation representing the likely or possible cause of death. Our findings establish the histological phenotype of lethal vaccination-associated myocarditis. Standardized autopsies Performed on 25 persons 25 bodies found unexpectedly dead at home, within 20 days following SARS-CoV-2 vaccination Histology Patchy, focal, interstitial myocardial T-lymphocytic and macrophage infiltration, predominantly of the CD4 positive sub- set, (T Helper cells) associated with mild myocyte damage. Autopsy findings indicated Death due to acute arrhythmogenic cardiac failure. Thus Myocarditis can be a potentially lethal complication following mRNA-based anti-SARS-CoV-2 vaccination. Our findings may aid in adequately diagnosing unclear cases after vaccination, and in establishing a timely diagnosis in vivo, thus, providing the framework for adequate monitoring and early treatment of severe clinical cases.

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