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Risk factors and clinical features https://www.imperial.ac.uk/news/197216/being-male-overweight-lead-more-serious/ https://www.medrxiv.org/content/10.1101/2020.04.23.20076042v1 Features of 16,749 hospitalised UK patients with COVID-19 (Imperial college, 28th April) Prospective observational cohort study The largest detailed description of COVID-19 in Europe 166 UK hospitals 6th February to18th April 2020 N = 16,749 people hospitalised with COVID-19 This represents 14.7% of all people who have tested positive for COVID-19 in the UK 239 patients (2.0%) under 18 years 139 patients (1.1%) are under 5 years of age Men 60.2%, women 39.8% Results Median age 72 years IQR 57 – 82 Median duration of symptoms before admission was 4 days IQR 1- 8 Median duration of hospital stay 7 days Commonest comorbidities Chronic cardiac disease, 29% Uncomplicated diabetes, 19% Non-asthmatic chronic pulmonary disease, 19% Asthma, 14% No documented reported comorbidity, 47% Increased age and comorbidities including obesity were associated with a higher probability of mortality Clinical features Cough, 70% Fever 69% Shortness of breath 65% High degree of overlap between the three common symptoms Reported no symptoms, 4% Clusters of symptoms were found 1. The most common symptom cluster encompass the respiratory system: cough, sputum, shortness of breath, fever, sore throat, runny nose, ear pain, wheeze, chest pain 2. Musculoskeletal symptoms: myalgia, joint pain and fatigue 3. Enteric symptoms: abdominal pain, vomiting and diarrhoea 29% of all patients complained of enteric symptoms on admission, mostly in association with respiratory symptoms 4% of all patients described enteric symptoms alone. Outcomes 49% discharged alive 33% died 17% continued to receive care 17% required admission to High Dependency or Intensive Care Units of these 31% were discharged alive 45% died 24% continued to receive care Of those receiving mechanical ventilation, 20% were discharged alive 53% died 27% remained in hospital Pregnant women 6% Pregnancy was not associated with mortality, in apparent contrast with influenza

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