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Explore REC-4881 in FAP: Data Update Webinar with 3,960 views, 77 likes, and 0 comments. Experience the impact of this video content that has captured audience attention.

On December 8, 2025, Recursion announced positive Phase 1b/2 data from the ongoing TUPELO trial of REC-4881, an investigational allosteric MEK1/2 inhibitor for familial adenomatous polyposis (FAP). In the Phase 2 portion of the study, REC-4881 demonstrated rapid and durable reductions in polyp burden, with 43% median reduction in evaluable patients after 12 weeks of treatment. 75% of evaluable patients had a reduction in polyp burden in this same period. Importantly, the effect persisted well beyond the dosing period: 82% of evaluable patients (9 of 11) maintained reductions at Week 25—12 weeks after stopping therapy—with a 53% median decrease from baseline. These results are especially meaningful when considered alongside real-world natural history analyses showing that untreated FAP patients are expected to experience increases when left untreated. REC-4881 (4 mg QD) has a safety profile consistent with MEK1/2 inhibition, with the majority of treatment-related adverse events being Grade 1 or 2. The most frequent TRAEs (≥10%) included dermatitis acneiform, rash and blood CPK increase. Grade 3 events occurred in 15.8% of the safety-evaluable patients, and no Grade ≥4 TRAEs reported to date. Read the full press release: https://ir.recursion.com/news-releases/news-release-details/positive-phase-1b2-results-ongoing-rec-4881-tupelo-trial-0

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