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ONS antibody survey, May 18th https://www.ons.gov.uk/peoplepopulationandcommunity/healthandsocialcare/conditionsanddiseases/articles/coronaviruscovid19/latestinsights#antibodies 19th April 69.3% in England 63.2% in Wales 63.5% in Northern Ireland 59.2% in Scotland Highest in the older age groups across the UK Similar across English regions, 64.8% in the South West to 69.7% in the North West. Infection or vaccination? Vaccinations now https://coronavirus.data.gov.uk/details/vaccinations First dose 69.9 % Second dose 39.0 % Positive tests Down 2.6% in past 7 days Next stage of roadmap https://www.theguardian.com/politics/live/2021/may/18/uk-covid-live-news-local-lockdowns-indian-variant-latest-updates-live Government, clearer idea of India variant threat in a few days’ time 21st June? Bolton Highest infection rate in UK Hospitalised 2 weeks ago, 13 Today, 24 India https://www.theguardian.com/world/live/2021/may/18/coronavirus-live-news-india-suffers-record-daily-deaths-tokyo-doctors-call-for-olympics-to-be-cancelled Deaths, + 4,329 Highest so far A 'massive' discrepancy in the death toll https://www.bbc.co.uk/news/world-asia-india-57154564 Unlikely to resume vaccines exports until at least October COVAX implications Cyclone Gujarat, patients cleared to 5 km from cost Mumbai moved 600 Covid-19 patients from field hospitals Two people have died in Nepal Taiwan Cases, + 206 + 335 + 240 = 2,257 Deaths, + 2 All schools closed until June Egypt Prioritising vaccination of tourism workers Fully vaccinating two resort areas Germany Offering vaccines to all adults from 7 June Delaying second Pfizer vaccines Birmingham University https://www.nature.com/articles/d41586-021-01299-y https://medicalxpress.com/news/2021-04-dual-dose-pfizer-covid-vaccine.html https://www.birmingham.ac.uk/news/latest/2021/05/covid-pfizer-vaccination-interval-antibody-response.aspx 12 weeks significantly increases antibody responses in older people 175 vaccine recipients older than 80 Received second dose of Pfizer Either 3 weeks or 11–12 weeks after first dose Outcomes, levels of antibodies against the SARS-CoV-2 spike protein T cells Peak antibody levels were 3.5 times higher 12 weeks versus 3 weeks Peak T-cell response was lower in 12 week group But antibodies maintained for 9 weeks after second vaccine (Other countries may have different vaccines and variants and social conditions) Stephen Griffin, virologist, University of Leeds People are theoretically vulnerable between their first and second jab What’s worked in the UK is maintaining restrictions at the same time as vaccinating

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