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Explore A Man Drank Throat Numbing Spray While Eating Spicy Food. This Is What Happened To His Brain. with 4,620,287 views, 112,001 likes, and 9,135 comments. Experience the impact of this video content that has captured audience attention.

Patient RJ by Jake Rattan, Friend 1 by Matt Hernandez, Food Enjoyer by Lexi Richmond, PA/Friend 4 by Luke Menzies Mark Rober Hot Ones: https://www.youtube.com/watch?v=CJbP71RI-V4 Peer Review: Dr Araceli Morga Vera, Dr Yue Wu, Dr Katherine Johns Spanish translation and dub: Cenzontle Voices Inc, CDMX Portugese translation and dub: George Frederico Music by @Lifeformed ► https://lifeformed.bandcamp.com In-depth (podcast) channel @HemeReview Secret Channel @BigEmus Medicine ► https://www.youtube.com/playlist?list=PL26HeTCO57qcMQB6CrU6QRzEi9tt9l1FI There's a secret version of this video in 8k: https://youtu.be/EA4y7gzbog0 the music levels were out of whack on that one so I elected to publish this one instead 0:00 Throat Numbing Spray Label 0:14 A Man Swallowed 1 Bottle Throat Numbing Spray While Eating Spicy Food 2:00 haha spray go glug 😳 glug 3:29 The emergency room 🚑 where we are now 4:10 Cyanosis and oxygen saturation 5:05 Arterial blood gas vs oxygen saturation 5:58 ...but something's wrong 6:38 This brings us back to the spray... 7:16 I promise you that stuff you learned in high school chemistry was worth it because it applies here 10:07 What does the throat numbing spray have to do with this? 12:10 ONOO😞- (Biochemical breakdown) 14:49 Throat numbing spray misuse isn't new 15:52 When you misuse the antidote and it becomes a poison itself Some images by Getty Images These cases are patients who I, or my colleagues have seen. They are de-identified and many instances have been presented in more depth in an academic setting. These videos are not individual medical advice and are for general educational purposes only. I do not give medical advice over the internet. References: Benzocaine-induced Methemoglobinemia. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1586795/ Reported Adverse Event Cases of Methemoglobinemia Associated With Benzocaine Products. https://jamanetwork.com/journals/jamainternalmedicine/fullarticle/217060 Safety Information on Benzocaine-Containing Products. https://www.fda.gov/drugs/postmarket-drug-safety-information-patients-and-providers/safety-information-benzocaine-containing-products Benzocaine. https://www.cureus.com/articles/68795-a-rare-case-of-benzocaine-induced-methemoglobinemia Continuous Methylene Blue Infusions for Treating Recurrent Methemoglobinemia. https://toxandhound.com/toxhound/refractory-methemoglobinemia/ Methemoglobinemia https://emcrit.org/ibcc/methemoglobinemia/ Pulse Oximetry https://emcrit.org/pulmcrit/pulse-oximetry/ Characterization of the methemoglobin forming metabolites of benzocaine and lidocaine. https://www.tandfonline.com/doi/abs/10.1080/00498254.2016.1196402 Identification of N-Hydroxy-para-aminobenzoic acid in a cyanotic child after benzocaine exposure. https://pubmed.ncbi.nlm.nih.gov/25211007/ A mitochondrial superoxide theory for oxidative stress diseases and aging. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4306659/ 4.2 Oxygen Binding: https://chem.libretexts.org/Bookshelves/General_Chemistry/Book%3A_Structure_and_Reactivity_in_Organic_Biological_and_Inorganic_Chemistry_(Schaller)/V%3A__Reactivity_in_Organic_Biological_and_Inorganic_Chemistry_3/04%3A_Oxygen_Binding_and_Reduction/4.02%3A_Oxygen_Binding Benzocaine Label without Methemoglobinemia warning: https://fda.report/DailyMed/29890aa7-915a-46db-943d-a041d42f3637 Acute Phenol Poisoning: https://www.jstor.org/stable/27720955 Goldfrank's Toxicologic Emergencies 11th Edition Text Methemoglobinemia. UpToDate. Accessed 01 Feb 2023.

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