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Behavioral and Health Outcomes of mRNA COVID-19 Vaccination: A Case-Control Study in Japanese Small and Medium-Sized Enterprises Published: December 13, 2024 https://www.cureus.com/articles/313843-behavioral-and-health-outcomes-of-mrna-covid-19-vaccination-a-case-control-study-in-japanese-small-and-medium-sized-enterprises?utm_source=substack&utm_medium=email#!/ Understanding the impact of messenger RNA (mRNA) COVID-19 vaccination, to urgently evaluate the effects, ? COVID-19 infection rates ? related behaviors changes Results N = 913 participants Adjusted ORs for COVID-19 infection among vaccinated individuals, compared to unvaccinated individuals 1.85 (p less than 0.001) A higher percentage of participants who contracted COVID-19 had received at least one dose of the vaccine Odds of contracting COVID-19 increased with the number of vaccine doses: One to two doses, OR: 1.63, (p = 0.020) Three to four doses, OR: 2.04, (p = 0.001) Five to seven doses, OR: 2.21, (p = 0.033). Behavioral analysis indicated that a reduced frequency of bathing and exercising, was significantly associated with higher COVID-19 infection rates i.e. bathing frequency and exercising were preventative for infection Negative efficacy Conclusions The study observed a higher reported incidence of COVID-19 infection among vaccinated individuals during the pandemic period Infections positivily corelated with number of vaccine does This paradoxical finding may be influenced by various factors, including immune response mechanisms, increasing T suppressor (regulatory cells) antibody-dependent enhancement (ADE), original antigenic sin, behavioral changes, exposure risk. Understanding these factors is crucial for urgently enhancing public health strategies and vaccination programs. Methods A case-control study Data collected from Japan Small and Medium Enterprise Management Council, December 2023. Survey gathered information on demographic characteristics, COVID-19 infection status, vaccination history, health status before January 2020, various preventive behaviors. Primary outcome, presence or absence of COVID-19 infection. Association between vaccination status and COVID-19 infection. Cleveland Clinic https://www.medrxiv.org/content/10.1101/2021.06.01.21258176v3 Health-care workers 1,359 unvaccinated, who had previously tested positive, non got infected The study authors concluded: “individuals who have had SARS-CoV-2 infection are unlikely to benefit from covid-19 vaccination.”

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