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Stochastic Thermodynamics Across Scales: From Fluctuations to Noneq... | Prof. Massimiliano Esposito Analytics Table

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Date: 31 July, 2026 Speaker: Prof. Massimiliano Esposito (University of Luxembourg) Stochastic thermodynamics (ST) provides a framework to describe energy, entropy, and irreversibility in systems dominated by fluctuations. Originally developed for small systems, it has led to general results such as fluctuation theorems, thermodynamic uncertainty relations, and nonequilibrium fluctuation–response relations. In this talk, I will first introduce the foundations of ST at the microscopic level and review these key results. I will then show how the theory naturally extends beyond the small-scale regime by connecting it to large deviation theory. This perspective reveals how macroscopic nonequilibrium thermodynamics—and in particular the structure of macroscopic fluctuations—emerges from an underlying stochastic description, providing a unified view across scales. In the second part of the talk, I will illustrate how this framework can be used to address concrete problems. I will discuss the thermodynamic cost of information processing, with an emphasis on modern low-power CMOS devices, and the thermodynamics of cellular metabolism, where energy transduction and regulation operate far from equilibrium. These examples highlight how stochastic thermodynamics can serve not only as a conceptual framework, but also as a tool to analyse and design complex physical and biological systems.

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