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More children suffered a severe reaction to vaccine than required oxygen therapy https://www.nejm.org/doi/full/10.1056/NEJMoa2203209?query=TOC&cid=NEJM%20eToc,%20July%2021,%202022%20DM1270826_NEJM_Non_Subscriber&bid=1076921524 BNT162b2 messenger RNA (mRNA) vaccine (Pfizer–BioNTech) 20th July 2022 Data on the real-world effectiveness of vaccines against omicron in children METHODS January 21, 2022, through April 8, 2022 Singapore, 5 to 11 years N= 255,936 children Fully vaccinated, 67.7% (173, 268) Partially vaccinated, 12% (30,712) Unvaccinated, 20.3% (51,995) 16.4 to 17.9 million person-days at risk 53,429 infections 5,342 PCR-confirmed 288 hospitalizations Among hospitalized children Five received supplemental oxygen four of whom, admitted ITU Of these five children One was unvaccinated Two were partially vaccinated Two were fully vaccinated No deaths attributable to Covid-19 Among the children in the unvaccinated group (per 1 million person-days) All reported infections, 3,303 PCR-confirmed infections, 479 Hospitalizations, 30 Among the children in the fully vaccinated group All reported infections, 2,770 PCR-confirmed infections, 112 Hospitalizations, 6.6 Vaccine efficacy against hospitalization Partially vaccinated v unvaccinated children All reported infections, 13.6% PCR-confirmed infections, 24.3% Hospitalizations, 42.3% In fully vaccinated children All reported infections, 36.8% PCR-confirmed infections, 65.3% Hospitalizations, 82.7% Vaccine effectiveness against all confirmed infections Fully vaccinated v unvaccinated group At times after 2nd dose of vaccine 7 to 14 days, 48.9 % 15 to 29 days, 37.6% 30 to 59 days, 28.5% 60 days or more, 25.6% CONCLUSIONS During a period when the omicron variant was predominant, BNT162b2 vaccination reduced the risks of SARS-CoV-2 infection and Covid-19–related hospitalization among children 5 to 11 years of age. these findings suggest greater vaccine effectiveness against higher levels of disease severity, The results of this study may provide insights to enable decision makers to weigh the benefits against the potential risks of vaccination of children. In Singapore, 22 serious adverse events after vaccination (0.005% of all doses administered) 0.05 in 1,000 0.5 in 10,000 5 in 100,000 among children 5 to 11

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