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Vitamin D, blood levels

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Vitamin D tests used in this video Your personalised vitamins https://www.yourpersonalisedvitamins.co.uk/ Single test, £39.99 Year plan, 2 tests and vitamin D supplies to titrate, £75 BetterYou test £32.95 https://betteryou.com/products/vitamin-d-test-kit?gclid=CjwKCAiA65iBBhB-EiwAW253W3gPTuiL_PONPgYXrj3XYbNv5vs43vvcc8mwv6gHPckgEqEnxPyMGBoCGUUQAvD_BwE Vitamin D into the body D3 (cholecalciferol), sun, animals or supplement D2 (ergocalciferol), plants, supplements Pathway In the skin Vitamin D, cholecalciferol, synthesised in the skin In the liver Converted to its major circulating form, 25-hydroxyvitamin D (25(OH)D) Calcifediol In the kidneys Converted into 1,25-dihydroxyvitamin D3, or calcitriol, the principal active hormonal form of vitamin D Vitamin D in the blood 25 hydroxy vitamin D 25-hydroxyvitamin D (25OHD) Calcifediol Circulating concentration of 25OHD is the accepted biomarker for vitamin D status https://medlineplus.gov/ency/article/003569.htm Many experts recommend a level between 20 and 40 ng/mL (50 to 100 nmol/L) Others recommend a level between 30 and 50 ng/mL (75 to 125 nmol/L) Some say higher https://www.hindawi.com/journals/dm/2015/864370/ Serum concentrations, units Nanograms per milliliter (ng/mL) (1000 ng = 1 microgram) Nanomoles per liter (nmol/L) 1 ng/mL is equal to 2.5 nmol/L Supplements Micrograms International units 400 IU = 10 mcg 1,000 IU = 25 mcg 2,000 IU = 50 mcg 4,000 IU = 100 mcg How much to take in Winter? https://www.nhs.uk/conditions/vitamins-and-minerals/vitamin-d/ Do not take more than 100 micrograms (4,000 IU) of vitamin D a day (11 years to adults) Children aged 1 to 10 years should not have more than 50 micrograms (2,000 IU) a day. Infants under 12 months should not have more than 25 micrograms (1,000 IU) a day. Prostate cancer https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1472821/ Colon cancer https://www.dana-farber.org/newsroom/news-releases/2019/high-dose-vitamin-d-shows-benefit-in-patients-with-advanced-colorectal-cancer/ Breast cancer https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5802611/ Multiple sclerosis https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5990512/ Heart disease https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2851242/ Immunity https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3166406/ Autoimmunity https://ard.bmj.com/content/70/9/1569 Diabetes https://pubmed.ncbi.nlm.nih.gov/32080077/ Chronic pain and sleep https://pubmed.ncbi.nlm.nih.gov/22699141/ Depression https://www.jneuropsychiatry.org/peer-review/depression-and-vitamin-d-deficiency-causality-assessment-and-clinical-practice-implications-12051.html Cytokine storm https://www.medrxiv.org/content/10.1101/2020.04.08.20058578v4 COVID https://www.nhs.uk/conditions/coronavirus-covid-19/people-at-higher-risk/get-vitamin-d-supplements/

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