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Prices, Pfizer and Moderna raise price of vaccines https://www.telegraph.co.uk/global-health/science-and-disease/coronavirus-news-nhs-double-covid-vaccine-uk-cases-isolation/ European Union supply contracts One Pfizer shot now 19.50 euros (£16.65) Up from 15.50 euros previously One Moderna dose £18.30 Up from about £16 in the first procurement deal Joint Committee on Vaccination and Immunisation https://www.gov.uk/government/news/statement-on-offering-covid-19-vaccination-to-young-people https://www.gov.uk/government/publications/jcvi-statement-august-2021-covid-19-vaccination-of-children-and-young-people-aged-12-to-17-years https://www.bbc.co.uk/news/uk-58091693 16 and 17-year-olds in the UK will be offered a first dose soon 1.4 million will be eligible Prof Jonathan Van-Tam We have the supply and I'm expecting this to start in a very short number of weeks indeed There is no time to waste in getting on with this I want us to proceed as fast as is practically possible Pfizer-BioNTech only Routinely vaccinating children over 12 United States since May France Italy, Brazil, Japan, Israel, Hong Kong Vaccine safety https://www.gov.uk/government/publications/jcvi-statement-august-2021-covid-19-vaccination-of-children-and-young-people-aged-12-to-17-years/jcvi-statement-on-covid-19-vaccination-of-children-and-young-people-aged-12-to-17-years-4-august-2021 The Pfizer-BioNTech BNT162b2 vaccine is administered via intramuscular injection, usually in the upper arm. Most frequent reactions aged 12 to 17 years Injection site pain, fever and headache Generally mild, self-limiting and short-lived, (1 to 2 days) FDA data on pericarditis and myocarditis https://www.fda.gov/news-events/press-announcements/coronavirus-covid-19-update-june-25-2021 Onset of symptoms within a few days after vaccination Particularly following the second dose Chest pain, shortness of breath, or feelings of having a fast-beating, fluttering, or pounding heart Pfizer-BioNTech BNT162b2 and Moderna mRNA- 1273 https://www.gov.uk/government/publications/coronavirus-covid-19-vaccine-adverse-reactions These extremely rare adverse reactions have been more frequent shortly after the second dose, and in younger individuals and males 60 cases per million https://www.cdc.gov/mmwr/volumes/70/wr/mm7027e2.htm 6 or 7 times more common after the second dose 1 in 16,666 1.4 million will be eligible = 84 cases The mechanism of action underlying these rare events is not currently known Israel and the United States have reported most of the cases Milder phenotype Vast majority recovering swiftly from the acute episode, compared to more typical cases of myocarditis Benefits of vaccination Secondary school-aged children in England (early July) Antibody positive is approximately 40% England, February 2020 and March 2021 61 deaths after testing positive https://www.medrxiv.org/content/10.1101/2021.07.07.21259779v1 22 from acute infection and three from PIMS mortality rate of 2/million for the 12,023,568 CYP living in England Survival rate after testing positive = 99·995% Second wave, hospitalisation rate, 100 to 400 per million Severe neuro-disabilities, Down’s Syndrome, underlying conditions resulting in immunosuppression, severe learning disabilities March 2020 TO July 2020 449 cases of PIMS in persons under 16 years 44% were admitted to paediatric intensive care Overall case fatality ratio was 1.1% Existing studies suggest that longer term (more than 8 weeks) symptoms following SARS-CoV2 infection occur in about 1% to 10% of persons after COVID-19 Avoiding school and class-based measures Benefits to adult is highly uncertain UK, cases up a bit today https://coronavirus.data.gov.uk Includes lateral flow tests https://ourworldindata.org/coronavirus Tuesday, 4th August, + 29,312 Monday 3rd August, 21,691

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