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True Facts: The Ferret and the Plague

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Donate to save the ferrets! https://wwf.help/ferrets WWF-US / Conservation Media USFWS Mountain-Prairie Colorado Parks and Wildlife (CPW) Wikimedia Commons Pond5 Envato Elements Citations: Babic A, Lindner AB, Vulic M, Stewart EJ, Radman M. Direct visualization of horizontal gene transfer. Science. 2008 Mar 14;319(5869):1533-6. doi: 10.1126/science.1153498. PMID: 18339941. Bland DM, Jarrett CO, Bosio CF, Hinnebusch BJ. Infectious blood source alters early foregut infection and regurgitative transmission of Yersinia pestis by rodent fleas. PLoS Pathog. 2018 Jan 22;14(1):e1006859. doi: 10.1371/journal.ppat.1006859. PMID: 29357385; PMCID: PMC5794196. Bland DM, Hinnebusch BJ (2016) Feeding Behavior Modulates Biofilm-Mediated Transmission of Yersinia pestis by the Cat Flea, Ctenocephalides felis. PLoS Negl Trop Dis 10(2): e0004413. doi:10.1371/journal.pntd.0004413 Brito IL. Examining horizontal gene transfer in microbial communities. Nat Rev Microbiol. 2021 Jul;19(7):442-453. doi: 10.1038/s41579-021-00534-7. Epub 2021 Apr 12. PMID: 33846600. Cavanaugh,D.C.,andJ.E.Williams.1980.Plague:someecologicalin-terrelationships,p.245–256.InR.TraubandH.Starcke(ed.),Fleas.ProceedingsoftheInternationalConferenceonFleas.A.A.Balkema,Rotterdam,TheNetherlands Chen TH, Elberg SS. Scanning electron microscopic study of virulent Yersinia pestis and Yersinia pseudotuberculosis type 1. Infect Immun. 1977 Mar;15(3):972-7. doi: 10.1128/iai.15.3.972-977.1977. PMID: 858647; PMCID: PMC421467. Jarrett CO, Deak E, Isherwood KE, Oyston PC, Fischer ER, Whitney AR, Kobayashi SD, DeLeo FR, Hinnebusch BJ. Transmission of Yersinia pestis from an infectious biofilm in the flea vector. J Infect Dis. 2004 Aug 15;190(4):783-92. doi: 10.1086/422695. Epub 2004 Jul 12. PMID: 15272407. Eddy JL, Gielda LM, Caulfield AJ, Rangel SM, Lathem WW. Production of outer membrane vesicles by the plague pathogen Yersinia pestis. PLoS One. 2014 Sep 8;9(9):e107002. doi: 10.1371/journal.pone.0107002. PMID: 25198697; PMCID: PMC4157834. B. Joseph Hinnebusch, Clayton O. Jarrett, David M. Bland. 2017. “Fleaing” the Plague: Adaptations of Yersinia pestis to Its Insect Vector That Lead to Transmission*. Annual Review Microbiology. 71:215-232. https://doi.org/10.1146/annurev-micro-090816-093521 Mikaty G, Coullon H, Fiette L, Pizarro-Cerda ´ J, Carniel E (2021) The invasive pathogen Yersinia pestis disrupts host blood vasculature to spread and provoke hemorrhages. PLoS Negl Trop Dis 15(10): e0009832. https://doi.org/10.1371/journal.pntd.0009832 Miranda de Graaf, Relja Beck, Simone M Caccio, Birgitta Duim, Pieter LA Fraaij, Françoise S Le Guyader, Marc Lecuit, Jacques Le Pendu, Emmie de Wit, Constance Schultsz, Sustained fecal-oral human-to-human transmission following a zoonotic event,Current Opinion in Virology, Volume 22, 2017, ISSN 1879-6257, https://doi.org/10.1016/j.coviro.2016.11.001. Misselwitz B, Barrett N, Kreibich S, Vonaesch P, Andritschke D, Rout S, Weidner K, Sormaz M, Songhet P, Horvath P, Chabria M, Vogel V, Spori DM, Jenny P, Hardt WD. Near surface swimming of Salmonella Typhimurium explains target-site selection and cooperative invasion. PLoS Pathog. 2012;8(7):e1002810. doi: 10.1371/journal.ppat.1002810. Epub 2012 Jul 26. PMID: 22911370; PMCID: PMC3406100. Nuss AM, Schuster F, Roselius L, Klein J, Bücker R, Herbst K, et al. (2016) A Precise Temperature-Responsive Bistable Switch Controlling Yersinia Virulence. PLoS Pathog 12(12): e1006091. https://doi.org/10.1371/journal.ppat.1006091 Shannon JG, Bosio CF, Hinnebusch BJ. Dermal neutrophil, macrophage and dendritic cell responses to Yersinia pestis transmitted by fleas. PLoS Pathog. 2015 Mar 17;11(3):e1004734. doi: 10.1371/journal.ppat.1004734. PMID: 25781984; PMCID: PMC4363629. Waititu JK, Nilsson K, Larrouy-Maumus G, Costa TRD, Avican K. RfaH is essential for virulence and adaptive responses in Yersinia pseudotuberculosis infection. mBio. 2025 Nov 12;16(11):e0212225. doi: 10.1128/mbio.02122-25. Epub 2025 Sep 29. PMID: 41020597; PMCID: PMC12607645. Wang C, Stanciu CE, Ehrhardt CJ, Yadavalli VK. The effect of growth temperature on the nanoscale biochemical surface properties of Yersinia pestis. Anal Bioanal Chem. 2016 Aug;408(20):5585-91. doi: 10.1007/s00216-016-9659-9. Epub 2016 Jun 3. PMID: 27259520. Wei Y, Li J, Han Y, Song Y (2026) Characterization of YhcN in stress adaptation and its complex transcriptional regulation by SlyA in Yersinia pestis. Front. Cell. Infect. Microbiol. 16:1769634. doi: 10.3389/fcimb.2026.1769634

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